Meditrans Publication List

Journal Publications:

Journal Publications:

Agrawal, P., Strijkers, G.J., Nicolay, K. (2010). Chitosan-based systems for molecular imaging. Advanced Drug Delivery Reviews 62(1): 42-58.

Aime, S., Delli Castelli, D., Geninatti Crich, S., Gianolio, E. and Terreno, E. (2009). Pushing the Sensitivity Envelope of Lanthanide-Based Magnetic Resonance Imaging (MRI) Contrast Agents for Molecular Imaging Applications. Acc. Chem. Res., 42, 822-831.

Aime, S., Delli Castelli, D., Terreno, E. (2009). Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles. Methods Enzymol., 464, 194-210.

Banciu, M., Fens, M.H.A.M., Storm, G., Schiffelers, R.M. (2008). Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice. Journal of Controlled Release 127 (2), 131-136.

Banciu, M., Metselaar, J.M., Schiffelers, R.M. and Storm, G. (2008). Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice. Journal of Steroid Biochemistry and Molecular Biology 111, 101-110.

Banciu, M., Metselaar, J.M., Schiffelers, R.M. and Storm, G. (2008). Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue. Neoplasia 10, 108-117.

Banciu, M., Schiffelers, R.M., Metselaar, J.M., and Storm, G. (2008). Utility of targeted glucocorticoids in cancer therapy. J Liposome Res 18, 47-57.

Banciu, M., Schiffelers, R.M. and Storm, G. (2008). Investigation into the role of tumor-associated macrophages in the antitumor activity of doxil. Pharmaceutical Research 25, 1948-1955.

Barge, A., Tei, L., Upadhyaya, D., Fedeli, F., Beltrami, L, Stefania, R., Aime, S. and Cravotto, G. (2008). Bifunctional ligands based on the DOTA-monoamide cage. Org. Biomol. Chem. 6, 1176-1184.

Boye Jensen, L., Morck Nielsen, H. and Foged, C. (2008). Dendritic Nanostructures as Carriers of Genetic Medicine. Lægemiddelforskning 2008, 13-15.

Briley-Saebo, K.C., Geninatti-Crich, S., Cormode, D.P., Barazza, A., Mulder, W.J.M., Chen, W., Giovenzana, G.B., Fisher, E.A., Aime, S. and Fayad, Z.A. (2009). High-Relaxivity Gadolinium-Modified High-Density Lipoproteins as Magnetic Resonance Imaging Contrast Agents. J. Phys. Chem. B, 113, 6283-6289.

Buyens, K., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2009). Elucidating the encapsulation of siRNA in PEGylated cationic liposomes. Langmuir 25(9):4886-4891.

Buyens, K., Meyer, M., Wagner, E., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2009). Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy.Journal of Controlled Release 141(1): 38-41.

Coimbra, M., Kuijpers, S.A., van Seters, S.P., Storm G. and Schiffelers, R.M. (2009). Targeted Delivery of Anti-Inflammatory Agents to Tumors. Current Pharmaceutical Design 15, 1825-1843.

Crivello, A., Nervi, C., Gobetto, R., Geninatti Crich, S., Szabo, I., Barge, A., Toppino, A., Deagostino, A., Venturello, P. and Aime, S. (2009). Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane. J. Biol. Inorg. Chem., 14, 883-890.

Cun, D., Boye Jensen, L., Mørck Nielsen, H., Moghimi, M., and Foged, C., (2008). Polymeric Nanocarriers for siRNA Delivery: Challenges and Future Prospects. Journal of Biomedical Nanotechnology, 4, 1–18.

Deckers, R., Rome, C. and Moonen, C.T. (2008). The role of ultrasound and magnetic resonance in local drug delivery. J Magn Reson Imaging 27, 400-409.

Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E. and Aime, S. (2008). Metal containing nanosized systems for MR-Molecular Imaging Applications. Coordination Chemistry Reviews, 252, 2424–2443.

Delli Castelli, D., Terreno, E., Cabella, C., Chaabane, L., Lanzardo, S., Tei, L., Visigalli, M. and Aime, S. (2009). Evidence for in vivo macrophage mediated tumor uptake of paramagnetic/fluorescent liposomes. NMR Biomed., 22, 1084-1092.

Delli Castelli, D., Terreno, E., Carrera, C., Giovenzana, G., Mazzon, R., Rollet, S., Visigalli, M. and Aime, S. (2008). Lanthanide-Loaded Paramagnetic Liposomes as Switchable Magnetically Oriented Nanovesicles. Inorg. Chem., 47 (8), 2928–2930.

De Wolf, H.K., Johansson, N., Thong, A.T., Snel, C.J., Mastrobattista, E., Hennink, W.E. and Storm G. (2008). Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes. Pharmaceutical Research 25, 1654-1662.

De Wolf, H.K., Luten, J., Snel, C.J., Storm, G. and Hennink, W.E. (2008). Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice. Molecular Pharmaceutics 5, 349-357.

Digilio, G., Catanzaro, V., Fedeli, F., Gianolio, E., Menchise, V., Napolitano, R., Gringeri, C. and Aime, S. (2009). Chem. Commun., 893-895.

Esposito, G., Geninatti Crich, S., and Aime, S. (2008). Efficient cellular labelling via CD44 receptors with cationic Liposomes functionalised with Hyaluronic Acid and loaded with contrast agents for MRI. Chemmedchem 3, 1858 – 1862.

Foged, C., Vader, P., and Schiffelers, R. (2009). Lipid-based Formulations for Delivery of siRNA. In: Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Joergensen, L. and Nielsen, H.M. (eds), Wiley.

Gianolio, E., Giovenzana, G.B, Ciampa, A., Lanzardo, S., Imperio, D., and Aime, S. (2008). A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface. Chemmedchem 3, 60-62.

Gianolio, E., Napolitano, R., Fedeli, F., Arena, F. and Aime, S. (2009). Poly-beta-cyclodextrin based platform for pH mapping via a ratiometric F-19/H-1 MRI method. Chem. Commun., 6044-6046.

Hak, S., Sanders, H.M.H.F., Agrawal, P., Langereis, S., Gruell, H., Keizer, H.M., Arena, F., Terreno, E., Strijkers, G.J., and Nicolay, K. (2009). A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging. Eur J Pharm Biopharm. 72 (2): 397-404.

Heeren, R.M.A., Smith, D.F., Stauber, J., Kükrer-Kaletas, B. and MacAleese, L. (2008). Imaging mass spectrometry: Hype or Hope? Journal of the American Society for Mass Spectrometry 20(6): 1006-1014.

Klerk, L. A., MacAleese, L., Lockyer, N. P., Kharchenko, A., Dankers, P. Y. W., Vickerman, J. C. and Heeren, R. M. A. (2010). C60+ secondary ion microscopy using a delay line detector. Anal. Chem., 82(3): 801-807.

Koçer, A. (2007). A remote controlled valve in liposomes for triggered liposomal release.J Liposome Research 17 (3), 219 – 225.

Koçer, A.(2009).Dr Armagan Kocer: revolutionising the way diseases are cured. research*eu FOCUS 3,22.

Koçer, A., Walko, M., Feringa, B.L. (2007). Synthesis and utilization of reversible and irreversible light-activated nanovalves derived from the channel protein MscL. Nature Protocols 2 (6), 1426-1437.

Lammers, T., Hennink, W.E., and Storm, G. (2008). Tumour-targeted nanomedicines: Principles and practice. Brit J Cancer 99, 392-397.

Lammers, T., Subr, V., Peschke, P., Kuehnlein, R., Ulbrich, K., Hennink, W.E., Kiessling, F., Heilmann, M., Debus, J., Huber, P.E., and Storm, G. (2008). Image-guided and passively tumor-targeted polymeric nanomedicines for radiochemotherapy. Brit J Cancer 99, 900-910.

Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Huber, P.E., Hennink, W.E. and Storm, G. (2009). Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials 30, 3466-3475.

Langereis, S., Keupp, J., van Velthoven, J.L.J., de Roos, I.H.C., Burdinski, D., Pikkemaat, J.A., Grüll, H. (2009). A Temperature-Sensitive Liposomal 1H CEST and 19F Contrast Agent for MR Image-Guided Drug Delivery. J. Am. Chem. Soc. 131(4),1380–1381.

Lentacker, I., Wang, N., Vandenbroucke, R.E., De Smedt, S.C., Sanders, N.N. (2009). Ultrasound exposure of lipoplex coated microbubbles: intracellular rerouting can bypass their endolysosomal degradation. Molecular Pharmaceutics 6 (2), 457–467.

MacAleese, L., Stauber, J. and Heeren, R.M.A. (2009). Perspectives for imaging mass spectrometry in the proteomics landscape. Proteomics 9, 819-834.

MEDITRANS (2009). Targeted Delivery of Nanomedicine (2007-2010). The Parliament Magazine Research Review 9: 44.

Merkel, O.M., Beyerle, A., Librizzi, D., Pfestroff, A., Behr, T.M., Sproat, B., Barth, P.J. and Kissel, T. (2009). Non-viral siRNA delivery to the lung – investigation of PEG-PEI polyplexes and their in vivo performance. Molecular Pharmaceutics 6(4): 1246-1260.

Merkel, O.M., Librizzi, D., Pfestroff, A., Schurrat, T., Buyens, K., Sanders, N.N., De Smedt, S.C., Béhé, M. and Kissel, T. (2009). Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-gpoly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging. Journal of Controlled Release 138(2): 148-159.

Mulder, W.J.M., Castermans, K., van Beijnum, J.R., Oude Egbrink, M.G.A., Chin, P.T.K., Fayad, E.Z.A., Lowik, C.W.G.M., Kaijzel, E.L., Storm, G., Strijkers, G.J., Griffioen, A.W. and Nicolay, K. (2009). Molecular imaging of tumor angiogenesis using avb3-integrin targeted multimodal quantum dots. Angiogenesis 12, 17-24,

Nolte-’t Hoen, E.N.M., Boot, E.P.J., Wagenaar-Hilbers, J.P.A., van Bilsen, J.H.M., Arkesteijn, G.J.A., Storm, G., Everse, L.A., van Eden, W. and Wauben, M.H.M. (2008). Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134. Journal of Leukocyte Biology 83, 1-10.

Oliveira, S., Høgset. A., Storm, G.and Schiffelers, R.M. (2008). Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo. Current Pharmaceutical Design 14, 3686-3697.

Paasonen, L., Romberg, B., Storm, G., Yliperttula, M., Urtti, A. and Hennink W.E. (2007). Temperature-Sensitive Poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-Coated Liposomes for Triggered Contents Release. Bioconjugate Chem., 18 (6), 2131–2136.

Pérez-Mayoral, E., Negri, V., Soler-Padrós, J., Cerdán, S. and Ballesteros, P. (2008). Chemistry of Paramagnetic and Diamagnetic Contrast Agents for Magnetic Resonance Imaging and Spectroscopy. pH Responsive Contrast Agents. European Journal of Radiology 67, 453 – 458.

Raemdonck, K., Demeester, J. and De Smedt, S.C. (2009). Advanced nanogel engineering for drug delivery. Soft Matter 5, 707–715.

Raemdonck, K., Naeye, B., Buyens, K., Vandenbroucke, R.E., Hogset, A., Demeester, J., and De Smedt, S.C. (2009). Biodegradable Dextran Nanogels for RNAi: Focus on Endosomal Escape and Intracellular siRNA Delivery. Advanced Functional Materials 19: 1406-1415.

Raemdonck, K., Vandenbroucke, R.E., Demeester, J., Sanders, N.N. and De Smedt, S.C. (2008). Maintaining the silence: reflections on long-term RNAi. Drug Discovery Today 13, 917-31.

Raemdonck, K., Van Thienen, T.G., Vandenbroucke, R.E., SandersN.N., Demeester, J., and De Smedt, S.C. (2008). Dextran Microgels for Time-Controlled Delivery of siRNA. Advanced Functional Materials 18 (7), 993 – 1001.

Righi,V., Roda, J.M., Paz, J., Mucci, A., Tugnoli, V., Rodriguea- Tarduchi, G., Barrios, L., Schenetti, L., Cerdán, S. and García-Martín, M.L. (2009). 1H HR-MAS and Genomic Analysis of human tumor biopsies discriminates between high and low grade astrocytomas. NMR in Biomedicine 22: 629-637.

Rodrigues, T.B., López-Larrubia, P. and Cerdán, S. (2009). Redox Dependence and Compartmentation of (13C) pyruvate in the brain of deuterated rats bearing C6 gliomas. J. Neurochem. 109 Suppl. 1: 237-245.

Romberg, B., Flesch, F.M., Hennink, W.E. and Storm, G. (2008). Enzyme-induced shedding of a poly(amino acid)-coating triggers contents release from dioleoyl phosphatidylethanolamine liposomes. International Journal of Pharmaceutics 355, 108-113.

Romberg, B., Hennink, W.E. and Storm, G. (2008). Sheddable coatings for long-circulating nanoparticles. Pharmaceutical Research 25, 55-71.

Schiffelers, R.M., de Wolf, H.K., van Rooy, I., and Storm, G. (2007). Synthetic delivery systems for intravenous administration of nucleic acids. Nanomedicine 2, 169-181.

Schiffelers, R.M. and Storm, G. (2008) Liposomal nanomedicines as anticancer therapeutics: Beyond targeting tumor cells. International Journal of Pharmaceutics 364, 258-264.

Stancanello, J., Terreno, E., Delli Castelli, D., Cabella, C., Uggeri, F., and Aime, S. (2008). Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images. Contr. Media Mol. Imaging 3, 136-149.

Stefania, R., Tei, L., Barge, A., Geninatti Crich, S., Szabo, I., Cabello, C., Cravotto, G., Aime, S. (2009). Tuning Glutamine Binding Modes in Gd-DOTA-Based Probes for an Improved MRI Visualization of Tumor Cells. Chemistry - A European Journal 15, 76-85.

Storm, G. (2007).EU Project MEDITRANS van start.Conceptuur51; 20.

Talelli, M., Rijcken, C.J.F, Lammers, T., Seevinck, P.R., Storm, G., van Nostrum, C.F., Hennink, W.E. (2009).Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: Towards a targeted nanomedicine suitable for image-guided drug delivery. Langmuir 25: 2060-2067.

Terreno, E., Barge, A., Beltrami, L., Cravotto, G., Delli Castelli, D., Fedeli, F., Jebasingh, B. and Aime, S. (2008). Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents. Chem. Commun. 600-602.

Terreno, E., Delli Castelli, D., Cabella, C., Dastru, W., Sanino, A., Stancanello, J., Tei, L., and Aime, S. (2008). Paramagnetic Liposomes as Innovative Contrast Agents for Magnetic Resonance (MR) Molecular Imaging Applications. Chem. Biodiv. 5, 1901-1912.

Terreno, E., Delli Castelli, D., Milone, L., Rollet, S., Stancello, J., Violante, E., and Aime, S. (2008). First ex-vivo MRI co-localisation of two LIPOCEST agents. Contrast Media and Molecular Imaging 3, 38-43.

Terreno, E., Delli Castelli, D., Violante, E., Sanders, H.M.H.F., Sommerdijk, N.A.J.M. and Aime, S. (2009). Osmotically Shrunken LIPOCEST Agents: An Innovative Class of Magnetic Resonance Imaging Contrast Media Based on Chemical Exchange Saturation Transfer. Chem. Eur. J., 15, 1440-1448.

Terreno, E., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M., Kok, M.B., Uggeri, F. and Aime, S. (2009). Methods for an improved detection of the MRI-CEST effect. Contrast Media Mol Imaging 4: 237-47.

Terreno, E., Sanino, A., Carrera, C., Delli Castelli, D., Giovenzana, G.B., Lombardi, A. Mazzon, R. Milone, L. Visigalli, M. and Aime, S. (2008). Determination of water permeability of paramagnetic liposomes of interest in MRI field. J Inorg Biochem. 102(5-6), 1112-1119.

Vandenbrouke, R.E., Lentacker, I., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2008). Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles. Journal of controlled release 126, 265-273.

Van Thienen, T.G., Demeester, J. and De Smedt, S.C. (2008). Screening poly(ethyleneglycol) micro- and nanogels for drug delivery purposes. Int J Pharm. 351(1-2), 174-185.

Van Thienen, T. G., Raemdonck, K., Demeester, J., and De Smedt, S. C. (2007). Protein Release from Biodegradable Dextran Nanogels. Langmuir, 23 (19), 9794 -9801.

Van Tomme, S., Metselaar, J.M., Schiffelers, R.M. and Storm, G. (2008). Liposomal corticosteroids as targeted anti-inflammatory nanomedicine. Eur. Journal of Nanomedicine 1, 15-19.

Wentzel, B. (2006). Utrecht coordineert Europees Nanomedicines project. Conceptuur 47; 24.

Zeilmaker, R. (2006).Nanomedicijnen: Geleide projectielen voor het lichaam. Intermediair 20; 48-49.

Forthcoming Journal publications:

Cun, D., Foged, C., Yang, M., Frøkjær, S. and Nielsen, H.M. (2009). Preparation and Characterization of Poly (DL-lactide-co-glycolide) for siRNA delivery. International Journal of Pharmaceutics In press

Cun, D., Krohn Jensen, D.M., Maltesen, M.J., Foged, C. and Nielsen, H.M. (2010). Quality by design: Optimization of poly(DL-lactide-coglycolide acid) nanoparticles for the sustained release of siRNA. Submitted

Foged, C. (2010). siRNA delivery with lipid-based systems: Promises and pitfalls, Current Topics in Medicinal Chemistry. Submitted.

Foged, C., Jing, X. and Nielsen, H.M. (2010). Cell-penetrating peptides for cytosolic delivery of biomacromolecules. In: Organelle-Specific Pharmaceutical Nanotechnology, Weissig, W. and D´Souza, G.G.M. (eds.), John Wiley & Sons House, submitted, Planned publication 2010, In press

Grüll, H., Langereis, S., Messager, L., Delli Castelli, D., Sanino, A., Torres, E., Terreno, E. and Aime, S. (2009). Block Copolymer Vesicles Containing Paramagnetic Lanthanide Complexes: A Novel Class of T1- and CEST MRI Contrast Agents. Submitted.

Jensen, D.M.K., Cun, D., Maltesen, M.J., Frøkjær, S., Nielsen, H.M. and Foged, C. (2009): Spray drying of siRNA-containing PLGA nanoparticles indented for inhalation. Journal of Controlled Release. In press

Kluza, E., van der Schaft, D.W.J., Hautvast, P.A.I., Mulder, W.J.M., Mayo, K.H., Griffioen, A.W., Strijkers, G.J. and Nicolay, K. (2009). Synergistic targeting of αvβ3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. Nanoletters In press

Leonhard, F., Collnot, E. and Lehr, C.-M. (2010). A 3-dimensional co-culture of enterocytes, monocytes and dendritic cells as in vitro model of the inflamed intestinal mucosa, Molecular Pharmaceutics, in preparation

Leonhard, F., Collnot, E. and Lehr, C.-M. (2010). A 3-dimensional co-culture of enterocytes, monocytes and dendritic cells to model the inflamed intestinal mucosa in vitro. Molecular Pharmaceutics, Submitted

Merkel, O.M., Librizzi, D., Pfestroff, A., Schurrat, T., Buyens, K., De Smedt, S.C., Béhé, M. and Kissel, T. (2009). Influence of in vivo stability of various PEI/siRNA complexes on pharmacokinetics and biodistribution – A correlation study of fluorescence fluctuation spectroscopy and nuclear imaging data. Journal of Controlled Release Submitted

Negri, V., Cerpa, A., López-Larrubia, P., Nieto, L., Cerdán, S. and Ballesteros, P. (2009). Paramagnetic Nanotubular Probes as Contrast Agents for Diffusion Tensor Magnetic Resonance Imaging. Angewandte ChemieIn press

Pacheco-Torres, J., López, P., Ballesteros, P. and Cerdán, S. (2009). Imaging Tumor Hypoxia by Magnetic Resonance Methods. NMR in Biomedicine In press

Reul, R., Roesler, S., Benfer, M., Nguyen, J., Schmehl, T., Gessler, T., Weissmann, N., Seeger, W., Fink, L. and Kissel, T. (2009). Expression of functional folate receptors on the apical side of the mouse lung demonstrated using folate -PEG-rhodamine conjugates. In press

Spijkers, L. J. A., van den Akker, R. F. P., Janssen, B. J. A., Debets, J. J., De Mey, J. G. R., Wijesinghe, D. S., Chalfant, C. E., MacAleese, L., Eijkel, G. B., Heeren, R. M. A., Alewijnse, A. E. and Peters, S. L. M. (2010). Pivotal role for sphingolipids in endothelium-dependent contractions and blood pressure regulation in spontaneously hypertensive rats. Submitted

Stauber, J. and Heeren, R.M.A. (2009). Chapter II-4: Metal Enhanced, Matrix Enhanced SIMS, and MALDI. In: Surface Analysis and Techniques in Biology. In press.

Stauber, J., MacAleese, L., Franck, J., Claude, E., Snel, M., Kükrer Kaletas, B., Wiel, I. M. V. D., Wisztorski, M., Fournier, I. and Heeren, R. M. A. (2009). On-Tissue Protein Identification and Imaging by MALDI-Ion Mobility Mass Spectrometry. J. Am. Soc. Mass Spectrom., In Press, Corrected Proof.

Strijkers, G.J., Kluza, E., Van Tilborg, G.A.F., Van der Schaft, D.W.J., Griffioen, A.W., Mulder, W.J.M. and Nicolay K. (2010). Multimodal liposomes for target­specific imaging and therapy of tumor angiogenesis. Angiogenesis, Submitted

Strijkers, G.J. and Nicolay, K. (2010). Relaxivity of Nanoparticles for Magnetic Resonance Imaging. In: Handbook of Nanophysics, 7 Volumes, 350 Chapters. Klaus D. Sattler, Editor. Taylor & Francis (CRC Press).

Tei, L., Mazooz, G., Barge, A., Shellef, Y., Ziv, K., Granot, D., Kalchenko, V., Dewhirst, M.W., Chaabane, L., Miragoli, L., Longo, D., Neeman, M. and Aime, S. (2009). Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity. In press

Van Thienen, T.G., Vercauteren, D., Van den Bossche, J., Thompson, D.H., Demeester, J. and De Smedt, S.C. (2009). Dextran nanogels with functional coatings: peg-lipid coated and ph sensitive lipid coated nanogels. International Journal of Pharmaceutics In press

Vercauteren, D., Vandenbroucke, R.E., Jones, A.T., Rejman, J., Demeester, J., De Smedt, S.C., Sanders, N.N. and Braeckmans, K.(2009).The use of inhibitors to study endocytic pathways of gene carriers: optimisation and pitfalls.Molecular Therapy In press

Conference publications:

Agrawal, P., Strijkers, G.J., van Lent, P., Blom, A., van den Berg, W., Crielaard, B., Lammers, T., Storm, G. and Nicolay, K. (2009). MRI to monitor Rheumatoid Arthritis disease progression and regression, following treatment with nanocarrier encapsulated drug. EuroNanoMedicine Abstract.

Agrawal, P., Strijkers, G.J., van Lent, P., Blom, A., van den Berg, W., Crielaard, B., Lammers, T., Storm, G. and Nicolay, K. (2009). Use of MRI and micro CT to monitor Rheumatoid Arthritis disease progression and regression in mice. ISMRM BENELUX Abstract.

Agrawal, P., Strijkers, G.J., van Lent, P., Blom, A., van den Berg, W., Storm, G. and Nicolay, K. (2008). MRI to monitor disease progress in a mouse model of Rheumatoid Arthritis. ISMRM Benelux, 10 December 2008, Antwerp, Belgium.

Amann, A. and Gress, C. (2008). Development and pre-validation of an in-vitro method for the prediction of drug-drug interactions and intestinal absorptions as a tool for drug candidate selection. 10th Expert meeting on Blood Brain Barrier and Caco-2, Bad Herrenalb, Germany.

Boye Jensen, L. (2008). Polypropylene imine dendrimers as carriers of siRNA. 7th International Conference and Workshop on Biological Barriers and Nanomedicine – Advanced Drug Delivery and Predictive non vivoTesting Technologies.

Boye Jensen, L., Mørck Nielsen, H., Boas, U., Cun, D., Pittelkow, M., Christensen, J.B., Frøkjær, S. and Foged, C. (2008). Investigations of Poly(propyleneimine) Dendrimers as Carriers for siRNA Delivery.7th International Conference and Workshop on Biological Barriers and Nanomedicine – Advanced Drug Delivery and Predictive non vivoTesting Technologies.

Boye Jensen, L., Mørck Nielsen, H., Boas, U., Cun, D., Pittelkow, M., Christensen, J.B., Frøkjær, S. and Foged, C. (2008). Investigations of Dendrimers as siRNA Delivery System. BIO-Dendrimer – 2008 Symposium on Biomedical Properties and Applications of Dendrimers, 3-5 July 2008, Lodz, Poland.

Buyens, K., Braeckmans, K., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2009). ‘Single particle tracking’ for studying the aggregation of cationic liposomes in whole blood. EuroNanoMedicine Abstract.

Chaabane, L., Adage, T., Aime, S., Greco, B. and Zaratin, P. (2008). 'Differential degree of Blood Brain Barrier permeability during Experimental Autoimmune Encephalomyelitis measured by Gadolinium-enhancement MRI', poster presented at the World Congress on Treatment and Research in Multiple Sclerosis ACTRIMS-ECTRIMS-LACTRIMS (Montreal, Sept. 2008).

Collnot, E.-M., Bur, M., Leonard, F., Schmidt, C., Stallmach, A. and Lehr, C.-M. (2009). Nanoparticle in men against inflammatory bowel diseases – a promising approach for the therapy of diarrhoea. Clinam Meeting.

Collnot, E.-M., Leonard, F., Lehr, C.-M., (2009). The intestinal ‘enhanced permeability and retention effect’: a passive targeting principle for PLGA nanocarriers in the treatment of inflammatory bowel disease. Clinam Meeting.

Crielaard, B., Yousefi, A., Schillemans, J., Lammers, T. and Storm, G. (2009). Interaction of liposomes with proteins measured by Surface Plasmon Resonance correlates with their in vivo circulation time. EuroNanoMedicine: Young researcher's technical workshop.

Czornak, K., Duursma, M. C., MacAleese, L., Boersema, P. J., Mohammed, S., Heck, A. J. R., Heeren, R. M. A. and Altelaar, A. F. M. (2009). Improved On-Tissue Protein Identification in MALDI Imaging Mass Spectrometry (MSI) using the Metalloendopeptidase Lys-N. 57th American Society for Mass Spectrometry (ASMS) Conference, 2009. Philadelphia, Pennsylvania (USA)

Folz, J., Bur, M., Collnot, E., Crielaard, B.J., Lammers, T., Storm G. and Lehr C.-M. (2009). Reduced phagocytosis of pegylated nanosized liposomes by alveolar macrophages.EuroNanoMedicine Abstract.

Foillard, S. and Doris, E. (2009). Drug Delivery Systems Based on Short Carbon Nanotubes. EuroNanoMedicine Abstract.

Giraud, S. and Maskrot, H. (2008). Synthesis of iron containing nanopowders by the laser pyrolysis method for biomedical applications. (Abstract) Particles 2008, USA

Giraud, S. Maskrot, H. Bonville, P. and Boulanger L. (2008). Characterization of inorganic magnetic nanoparticles produced by the laser pyrolysis method. International Conference on Safe production and use of nanomaterials, Nanosafe 2008 November 3-7, 2008 – Grenoble, France.

Gress, C. and Amann, A. (2008). Effects of different parameters in Caco-2 bi-directional permeability studies. 10th Expert meeting on Blood Brain Barrier and Caco-2, Bad Herrenalb, Germany.

Hak, S., Sanders, E., Agrawal, P., Langereis, S., Gruell, H., Keizer, H., Arena, F., Terreno, E., Strijkers, G.J. and Nicolay, K. (2008). A High Relaxivity Gd(III)DOTA-DSPE-Based Liposomal Contrast Agent for Target-Specific MRI. Abstract for 2008 World Molecular Imaging Congress, Sept. 10–13, Nice, France.

Jensen, D.M.K., Cun, D., Jensen, L.B., Frokjaer, S., Nielsen, H.M. and Foged, C. (2009). Spray drying preserves modified PLGA nanoparticles containing siRNA intended for inhalation and their gene silencing activity. EuroNanoMedicine Poster.

Jensen, L.B., Mortensen, K., Jensen, D.K., Nielsen, H.M. and Foged, C. (2009). Characterization of siRNA-Dendrimer complexes by SAXS analysis. Poster presentation at 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, Copenhagen, Denmark.

Jensen, L.B., Mortensen, K., Jensen, D.K., Nielsen, H.M. and Foged, C. (2009). Characterization of siRNA-Dendrimer Complexes by SAXS Analysis. CRS Abstract.

Jungmann, J. H., Gademann, G., Gijsbertsen, A., MacAleese, L., Heeren, R. M. A. and Vrakking, M. J. J. (2010). Photoelectron & ion imaging using CMOS pixel detectors. Physics@FOM 2010. Veldhoven (NL)

Jungmann, J. H., MacAleese, L. and Heeren, R. M. A. (2009). Towards High Spatial Resolution in Microscope Mode Imaging MS Using a Medipix Detector. International Mass Spectrometry Conference (IMSC), 2009. Bremen (De)

Keupp, J., Caruthers, S.D., Burdinski, D., Langereis, S., Pikkemaat, J.A., Lamerichs, R., Gruell, H., Wickline, S.A., Lanza, G.M. and Winter, P.M. (2008). Proceedings ISMRM 16th, 637.

Keupp, J., Langereis S., de Roos, I., Burdinski, D., Pikkemaat, J. and Gruell, H. (2009). 1H-CEST and 19F MRI of temperature-responsive liposomal contrast agents for image guided drug delivery. ISMRM Conference, Hawaii, 18-24 April 2009.

Kissel, T., Nguyen, J., Merkel, O., Benfer, M., Liu, Y., Endres, T. and Samsonova, O. (2009). Biodegradable nano-carriers for pulmonary drug and gene delivery. Abstract Symposium on Biomedical Polymers for Drug Delivery in Salt Lake City Utah (March 26-27, 2010).

Klerk, L. A., Jungmann, J. H., Kharchenko, A., MacAleese, L., Lockyer, N. P., Vickerman, J. C., Gademann, G., Vrakking, M. and Heeren, R. M. A. (2010). High resolution C-60 SIMS and MALDI mass microscopy using position-sensitive detectors. Physics@FOM 2010. Veldhoven (NL)

Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Kiessling, F., Huber, P.E., Hennink, W.E., and Storm, G. (2008). Carrier-based radiochemotherapy. CRS Abstract.

Langereis, S., de Smet, M., Keupp, J., Heijman, E. and Grüll, H. (2009). Magnetic Resonance guided Imaging of Temperature Induced Drug Delivery. 2009 World Molecular Imaging Congress (WMIC) in Montreal.

Lentacker, I., De Smedt, S.C. and Sanders N. (2009). Lipoplex loaded microbubbles for ultrasound triggered gene delivery.EuroNanoMedicine Abstract.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2008). Development of a novel 3D inflamed intestinal mucosa model: Initiation of inflammation in Caco-2 cells. 7th International Conference and Workshop on Biological Barriers and Nanomedicine – Advanced Drug Delivery and Predictive non vivoTesting Technologies.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2008). Development of a novel Caco-2 based 3D model of the inflamed intestinal mucosa: Initiation of inflammation. CRS Abstract.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2009). The intestinal ‘enhanced permeability and retention effect’: passive targeting of PLGA nanocarriers in the treatment of Crohn’s disease. EuroNanoMedicine Abstract.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2009). Development of a 3 D in vitro model of the inflamed colonic mucosa. EuroNanoMedicine: Young researcher's technical workshop.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2009). Development of a 3D in vitro model of the inflamed colonic mucosa. Congress on Alternatives & Animal Use in the Life Sciences Abstract. Rome.

MacAleese, L., Ballet, S., Corot, C. and Heeren, R. M. A. (2010). Imaging Mass Spectrometry and Nanomedicine: Contribution of Mass Spectrometry to Medical Imaging Techniques such as MRI. Physics@FOM 2010. Veldhoven (NL)

MacAleese, L., Ballet, S., Corot, C. and Heeren, R. M. A. (2009). Investigating Distribution and Concentration of MRI Contrast Agents In and Around Tumors by Imaging Mass Spectrometry. International Mass Spectrometry Conference (IMSC), 2009. Bremen (De)

MacAleese, L., Bot, M., Kharchenko, A., Biessen, E. A. L. and Heeren, R. M. A. (2009). Lipid Cartography of Atherosclerotic Plaques by ToF-SIMS Imaging Mass Spectrometry. Physics@FOM 2009. Veldhoven (NL)

MacAleese, L., Bot, M., Kharchenko, A., Biessen, E. A. L. and Heeren, R. M. A. (2009). Lipid Cartography of Atherosclerotic Plaques by ToF-SIMS Imaging Mass Spectrometry. Netherlands Proteomics Center Annual Meeting, 2009. Utrecht (NL)

MacAleese, L., Klerk, L. A., Smith, D. F., Duursma, M. C. and Heeren, R. M. A. (2009). LC-SIMS: a Tool for Molecular Identification, and Enhanced Impact of SIMS in Biological Fields. European Proteomics Association (EuPA), 2009. Stockholm (Sweden)

MacAleese, L., Klerk, L. A., Smith, D. F., Duursma, M. C. and Heeren, R. M. A. (2009). LC-SIMS: The Doors Wide Open for Biological Applications of SIMS in Imaging Mass Spectrometry. 57rd American Society for Mass Spectrometry (ASMS) Conference, 2009. Philadelphia, Pennsylvania (USA)

MacAleese, L., Stauber, J. and Heeren, R.M.A. (2008). Imaging MS/MS: challenges for on-tissue protein identification. HUPO 7th Annual World Congress, Amsterdam (NL) 16-20.08.08.

Merkel, O.M., Beyerle, A., Librizzi, D. and Kissel, T. (2009). Imaging-guided Gene & Cell based Therapies Nuclear Imaging of Intratracheal siRNA Delivery with PEG-PEI Copolymers. 4th European Molecular Imaging Meeting - Barcelona 27-30 May 2009.

Sheikhet Migalovich, H., Addadi, Y., Nevo, N., Ballet, S., Corot, C., Neeman, M. (2010). Loss of Selectivity for folate receptor tumor targeting of USPIO by Macrophage uptake. ISMRM – Stockholm, Sweden 1-7 May 2010.

Naeye B., Raemdonck K., Demeester, J., De Smedt S.C. (2008). Pegylation of biodegradable dextran nanogels for controlled siRNA release. ESF-UB conference: Nanomedicine 2008, Sant Feliu de Guixols, Spain.

Naeye B., Raemdonck K., and De Smedt S.C. (2009). Optimization of biodegrabable dextran nanogels for controlled siRNA delivery. EuroNanoMedicine Abstract.

Oerlemans, C., Nijsen, J.F.W., van Amersfoort, M., van Bloois, L., van den Bosch, M.A., Luijten, P.R. and Storm, G. (2009). Dye-containing liposomes for heat-triggered release.EuroNanoMedicine: Young researcher's technical workshop.

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Intracellular time-controlled delivery of siRNA from cationic nanogel depots. 11th annual Meeting of the American Society of Gene Therapy (ASGT), May 28-June 1, Boston, Massachusetts, USA

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Cytosolic nanogel depots for time-controlled siRNA delivery. 2nd International Symposium on Cellular Delivery of Therapeutic Macromolecules Cardiff University, June 22nd – June 25th

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Cytosolic nanogel depots for time-controlled siRNA delivery. September 16th – September 18th, Stockholm international fairs and congress center, Stockholm, Sweden.

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Cytosolic nanogel depots for time-controlled siRNA delivery. Right Symposium “RNA interference technology as Human Therapeutic Tool”, 3-5 November, The International Auditorium, Brussels

Raemdonck, K., Naeye B., Demeester, J., De Smedt, S.C. (2009). Evaluation of a dextran nanogel concept for intracellular siRNA delivery. EuroNanoMedicine Abstract.

Ratzinger, G., Agrawal, P., Wirth, M., Körner, W., Nicolay, K. and Gabor, F. (2009). Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging. Presented at the 21st Scientific Congress of the Austrian Pharmaceutical Society April 16th to April 18th 2009, Vienna, Austria.

Schiffelers, R., Oliveira, S., Woodle, M., Hogset, A. and Storm, G. (2008). TARGETED NANOMEDICINES DELIVERING siRNA. Potentiation of Silencing Activity by Photochemical Internalization. CRS Abstract.

Stauber, J., Klerk, L., van Bochove, G.S., Nicolay, K. and Heeren, R.M.A. (2008). A Combined Imaging Mass spectrometry and MRI study of nanoparticle based drug delivery
systems. HUPO 7th Annual World Congress, Amsterdam (NL) 16-20.08.08.

Stauber, J., Kükrer-Kaletas, B., van der Wiel, I.M., Heeren, R.M.A., Snel, M.F. and Claude, E. (2008).Ion mobility Imaging Mass Spectrometry: A New Tool for In situ Identification. 56th ASMS Conference on Mass Spectrometry and Applied Topics, Dencer, CO (USA). 1-5.06.08.

Stauber J., MacAleese L., Franck J., Snel M., Claude E., Kükrer Kaletas B., Wiel I. M. van der, Wisztorski M., Fournier I. and Heeren, R.M.A. (2008). Targeted Ion Mobility Imaging Mass Spectrometry: A new tool for In situ identification. HUPO 7th Annual World Congress, Amsterdam (NL) 16-20.08.08.

Storm, G. (2009). MEDITRANS: Targeted Delivery of Nanomedicine. EuroNanoMedicine Abstract.

UNITO (2007). Inclusion and Aggregation Properties of an Anionic Porphyrin with Ionic and Non-Ionic Cyclodextrin Vesicles for Diagnostic Applications. 19-22 September 2007 – Poster presented at the 8th National Congress on Supramolecular Chemistry held in Trieste (Italy).

Theses:

J. Griger. Master thesis, University of Copenhagen/Universität Hohenheim, Stuttgart, Germany, November 2009.

S.S. Oliveira. Utrecht 08-12-08. Title: Epidermal growth factor receptor: Target for delivery and silencing. Promotor: Prof. Dr. G. Storm. Copromotor, Dr. R.M. Schiffelers.

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An Integrated Project funded by the European Commission under the "nanotechnologies and nano-sciences, knowledge-based multifunctional materials and new production processes and devices" (NMP) thematic priority of the Sixth Framework Programme. Contract Number: NMP4-CT-2006-026668