Meditrans Publication List

Journal Publications:

Journal Publications:

Agrawal, P., Strijkers, G.J., Nicolay, K. (2010). Chitosan-based systems for molecular imaging. Advanced Drug Delivery Reviews 62(1): 42-58.

Aime, S., Delli Castelli, D., Geninatti Crich, S., Gianolio, E. and Terreno, E. (2009). Pushing the Sensitivity Envelope of Lanthanide-Based Magnetic Resonance Imaging (MRI) Contrast Agents for Molecular Imaging Applications. Acc. Chem. Res., 42, 822-831.

Aime, S., Delli Castelli, D., Terreno, E. (2009). Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles. Methods Enzymol., 464, 194-210.

Al-Soraj, M.H., Watkins, C.L., Vercauteren, D., De Smedt, S., Braeckmans, K. and Jones, A.T. (2010). siRNA versus pharmacological inhibition of endocytic pathways for studying cellular uptake of cell penetrating peptides and other drug delivery vectors. Drug discovery Today 15, 1103-1103.

Banciu, M., Fens, M.H.A.M., Storm, G., Schiffelers, R.M. (2008). Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice. Journal of Controlled Release 127 (2), 131-136.

Banciu, M., Metselaar, J.M., Schiffelers, R.M. and Storm, G. (2008). Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice. Journal of Steroid Biochemistry and Molecular Biology 111, 101-110.

Banciu, M., Metselaar, J.M., Schiffelers, R.M. and Storm, G. (2008). Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue. Neoplasia 10, 108-117.

Banciu, M., Schiffelers, R.M., Metselaar, J.M., and Storm, G. (2008). Utility of targeted glucocorticoids in cancer therapy. J Liposome Res 18, 47-57.

Banciu, M., Schiffelers, R.M. and Storm, G. (2008). Investigation into the role of tumor-associated macrophages in the antitumor activity of doxil. Pharmaceutical Research 25, 1948-1955.

Barge, A., Tei, L., Upadhyaya, D., Fedeli, F., Beltrami, L, Stefania, R., Aime, S. and Cravotto, G. (2008). Bifunctional ligands based on the DOTA-monoamide cage. Org. Biomol. Chem. 6, 1176-1184.

Berg, K., Weyergang, A., Høgset, A. and Selbo, P.K. (2010). The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines. In: Organelle-Specific Pharmaceutical Nanotechnology (Weissig, V. and D’Souza, G.G.M., eds.). Chapter 17, pp. 311-322. John Wiley & Sons, Inc.

Boye Jensen, L., Morck Nielsen, H. and Foged, C. (2008). Dendritic Nanostructures as Carriers of Genetic Medicine. Lægemiddelforskning 2008, 13-15.

Briley-Saebo, K.C., Geninatti-Crich, S., Cormode, D.P., Barazza, A., Mulder, W.J.M., Chen, W., Giovenzana, G.B., Fisher, E.A., Aime, S. and Fayad, Z.A. (2009). High-Relaxivity Gadolinium-Modified High-Density Lipoproteins as Magnetic Resonance Imaging Contrast Agents. J. Phys. Chem. B, 113, 6283-6289.

Buyens, K., Braeckmans, K., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2010). siRNA containing nanoparticles: stability of encapsulation and particle size. Drug discovery Today 15, 1081-1081.

Buyens, K., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2009). Elucidating the encapsulation of siRNA in PEGylated cationic liposomes. Langmuir 25(9): 4886-4891.

Buyens, K., Meyer, M., Wagner, E., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2009). Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy. Journal of Controlled Release 141(1): 38-41.

Coimbra, M., Banciu, M., Fens, M.H., de Smet, L., Cabaj, M., Metselaar, J.M., Storm, G. and Schiffelers, R.M. (2010). Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation. Journal of Control Release 148, 303-310.

Coimbra, M., Kuijpers, S.A., van Seters, S.P., Storm G. and Schiffelers, R.M. (2009). Targeted Delivery of Anti-Inflammatory Agents to Tumors. Current Pharmaceutical Design 15, 1825-1843.

Crielaard, B., Yousefi, A., Schillemans, J., Lammers, T. and Storm, G. (2010). Interaction of liposomes with proteins measured by surface plasmon resonance correlates with their in vivo circulation time. J Control Release 148, e31-32.

Crivello, A., Nervi, C., Gobetto, R., Geninatti Crich, S., Szabo, I., Barge, A., Toppino, A., Deagostino, A., Venturello, P. and Aime, S. (2009). Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane. J. Biol. Inorg. Chem., 14, 883-890.

Cun, D., Boye Jensen, L., Mørck Nielsen, H., Moghimi, M., and Foged, C., (2008). Polymeric Nanocarriers for siRNA Delivery: Challenges and Future Prospects. Journal of Biomedical Nanotechnology, 4, 1–18.

Cun, D., Foged, C., Yang, M., Frøkjær, S. and Nielsen, H.M. (2010). Preparation and Characterization of Poly (DL-lactide-co-glycolide) for siRNA delivery. International Journal of Pharmaceutics 390(1), 70-75.

Cun, D., Krohn Jensen, D.M., Maltesen, M.J., Bunker, M., Whiteside, P., Scurr, D., Foged, C. and Nielsen, H.M. (2011). High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: Quality by design optimization and characterization . European Journal of Pharmaceutics and Biopharmaceutics 77(1), 26-35.

Deckers, R., Rome, C. and Moonen, C.T. (2008). The role of ultrasound and magnetic resonance in local drug delivery. J Magn Reson Imaging 27, 400-409.

Delli Castelli, D., Dastrù, W., Terreno, E., Cittadino, E., Mainini, F., Torres, E., Spadaro, M. and Aime, S. (2010). In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labelled liposomes. J Control Release. 144(3), 271-279.

Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E. and Aime, S. (2008). Metal containing nanosized systems for MR-Molecular Imaging Applications. Coordination Chemistry Reviews, 252, 2424–2443.

Delli Castelli, D., Terreno, E. and Aime, S. (2011). Yb(III)-HPDO3A: a dual pH- and temperature-responsive CEST agent. Angew Chem Int Ed Engl. 50(8), 1798-1800.

Delli Castelli, D., Terreno, E., Cabella, C., Chaabane, L., Lanzardo, S., Tei, L., Visigalli, M. and Aime, S. (2009). Evidence for in vivo macrophage mediated tumor uptake of paramagnetic/fluorescent liposomes. NMR Biomed., 22, 1084-1092.

Delli Castelli, D., Terreno, E., Carrera, C., Giovenzana, G., Mazzon, R., Rollet, S., Visigalli, M. and Aime, S. (2008). Lanthanide-Loaded Paramagnetic Liposomes as Switchable Magnetically Oriented Nanovesicles. Inorg. Chem., 47 (8), 2928–2930.

De Wolf, H.K., Johansson, N., Thong, A.T., Snel, C.J., Mastrobattista, E., Hennink, W.E. and Storm G. (2008). Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes. Pharmaceutical Research 25, 1654-1662.

De Wolf, H.K., Luten, J., Snel, C.J., Storm, G. and Hennink, W.E. (2008). Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice. Molecular Pharmaceutics 5, 349-357.

Diaz-Moscoso, A., Vercauteren, D., Rejman, J., Benito, J.M, Ortiz Mellet, C., De Smedt, S.C. and Garcia Fernandez, J.M. (2010). Insights in cellular uptake mechanisms of pDNA - polycationic amphiphilic cylodextrin nanoparticles (CDplexes). Journal of Controlled Release 143 (3), 318-325.

Digilio, G., Catanzaro, V., Fedeli, F., Gianolio, E., Menchise, V., Napolitano, R., Gringeri, C. and Aime, S. (2009). Chem. Commun., 893-895.

Digilio, G., Menchise, V., Gianolio, E., Catanzaro, V., Carrera, C., Napolitano, R., Fedeli, F. and Aime, S. (2010). Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling. J Med Chem. 53(13), 4877-4890.

Dolman, M.E.M., Harmsen, S., Storm, G., Hennink, W.E. and Kok, R.J. (2010). Drug targeting to the kidney: advances in the active targeting of therapeutics to proximal tubular cells. Advanced Drug Delivery Reviews 62, 1344-1357.

Esposito, G., Geninatti Crich, S., and Aime, S. (2008). Efficient cellular labelling via CD44 receptors with cationic Liposomes functionalised with Hyaluronic Acid and loaded with contrast agents for MRI. Chemmedchem 3, 1858 – 1862.

Fens, M.H.A.M., Storm, G., Pelgrim, R.C.M., Ultee, A., Byrne, A.T., Gaillard, C.A., van Solinge, W.W. and Schiffelers, R.M. (2010). Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability. Experimental Hematology 38, 282-291.

Fens, M.H.A.M., Storm, G. and Schiffelers, R.M. (2010). Tumor vasculature as target for therapeutic intervention. Expert Opinion on Investigational Drugs 19, 1321-1338.

Figueiredo, S., Moreira, J.N., Geraldes, C.F., Aime, S. and Terreno, E. (2011). Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes. Bioorg Med Chem. 19(3), 1131-1135.

Foged, C., Jing, X. and Nielsen, H.M. (2010). Chapter 22: Cell-penetrating peptides for cytosolic delivery of biomacromolecules. In: Organelle-Specific Pharmaceutical Nanotechnology, Weissig, W. and D´Souza, G.G.M. (eds.), John Wiley & Sons, Inc., Hoboken, NJ, USA.

Foged, C., Vader, P., and Schiffelers, R. (2009). Lipid-based Formulations for Delivery of siRNA. In: Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Joergensen, L. and Nielsen, H.M. (eds), Wiley.

Fretz, M.M. and Storm, G. (2010). TAT-Peptide Modified Liposomes: Preparation, Characterization, and Cellular Interaction. In: Liposomes. Methods and Protocols. Vol. 1: Pharmaceutical Nanocarriers (Ed. V. Weissig), pp. 349-359, Humana Press, Springer ISSN 1064-3745.

Gianolio, E., Arena, F., Strijkers, G.J., Nicolay, K., Høgset, A. and Aime, S. (2011). Photochemical Activation of Endosomal Escape of MRI-Gd-agents in Tumor Cells. Magnetic Res. Med. 65, 212-219.

Gianolio, E., Giovenzana, G.B, Ciampa, A., Lanzardo, S., Imperio, D., and Aime, S. (2008). A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface. Chemmedchem 3, 60-62.

Gianolio, E., Maciocco, L., Imperio, D., Giovenzana, G.B., Simonelli, F., Abbas, K., Bisi, G. and Aime S. (2011). Dual MRI-SPECT agent for pH-mapping. Chem Commun 47(5), 1539-1541.

Gianolio, E., Napolitano, R., Fedeli, F., Arena, F. and Aime, S. (2009). Poly-beta-cyclodextrin based platform for pH mapping via a ratiometric F-19/H-1 MRI method. Chem. Commun., 6044-6046.

Grange, C., Geninatti-Crich, S., Esposito, G., Alberti, D., Tei, L., Bussolati, B., Aime, S. and Camussi, G. (2010). Combined delivery and magnetic resonance imaging of neural cell adhesion molecule-targeted doxorubicin-containing liposomes in experimentally induced Kaposi's sarcoma. Cancer Res. 70(6), 2180-2190.

Grüll, H., Langereis, S., Messager, L., Delli Castelli, D., Sanino, A., Torres, E., Terreno, E. and Aime, S. (2010). Block Copolymer Vesicles Containing Paramagnetic Lanthanide Complexes: A Novel Class of T1- and CEST MRI Contrast Agents. Soft Matter, 6, 4847-4850.

Hak, S., Sanders, H.M.H.F., Agrawal, P., Langereis, S., Gruell, H., Keizer, H.M., Arena, F., Terreno, E., Strijkers, G.J., and Nicolay, K. (2009). A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging. Eur J Pharm Biopharm. 72 (2): 397-404.

Heeren, R.M.A., Smith, D.F., Stauber, J., Kükrer-Kaletas, B. and MacAleese, L. (2008). Imaging mass spectrometry: Hype or Hope? Journal of the American Society for Mass Spectrometry 20(6): 1006-1014.

Jensen, D.M.K., Cun, D., Maltesen, M.J., Frøkjær, S., Nielsen, H.M. and Foged, C. (2010): Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation. Journal of Controlled Release, 142(1),138-145.

Jensen, L.B., Mortensen, K., Pavan, G.M., Kasimova, M.R., Jensen, D.K., Gadzhyeva, V., Nielsen, H.M. and Foged, C. (2010). Molecular Characterization of the Interaction between siRNA and PAMAM G7 Dendrimers by SAXS, ITC and Molecular Simulations. Biomacromolecules, 11, 3571–3577.

Jungmann, J.H., MacAleese, L., Buijs, R., Giskes, F., de Snaijer, A., Visser, J., Visschers, J., Vrakking, M.J.J. and Heeren, R.M.A. (2010). Fast, High Resolution Mass Spectrometry Imaging Using a Medipix Pixelated Detector. JASMS 21, 2023-2030.

Klerk, L.A., Dankers, P.Y.W., Popa, E.R., Bosman, A.W., Sanders, M.E., Reedquist, K.A. and Heeren, R.M.A. (2010). TOF-SIMS imaging of polymeric scaffolds with surrounding tissue after in-vivo implantation. Anal Chem. 82(11), 4337-4343.

Klerk, L. A., MacAleese, L., Lockyer, N. P., Kharchenko, A., Dankers, P. Y. W., Vickerman, J. C. and Heeren, R. M. A. (2010). C60+ secondary ion microscopy using a delay line detector. Anal. Chem., 82(3): 801-807.

Kluza, E., van der Schaft, D.W.J., Hautvast, P.A.I., Mulder, W.J.M., Mayo, K.H., Griffioen, A.W., Strijkers, G.J. and Nicolay, K. (2010). Synergistic targeting of αvβ3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. Nanoletters 10(1), 52-58.

Koçer, A. (2007). A remote controlled valve in liposomes for triggered liposomal release. J Liposome Research 17 (3), 219 – 225.

Koçer, A. (2009). Dr Armagan Kocer: revolutionising the way diseases are cured. research*eu FOCUS 3, 22.

Koçer, A., Walko, M., Feringa, B.L. (2007). Synthesis and utilization of reversible and irreversible light-activated nanovalves derived from the channel protein MscL. Nature Protocols 2 (6), 1426-1437.

Kostka, L., Cestmir, K., Subr, V., Spirkova, M., Addadi, Y., Neeman, M., Lammers, T. and Ulbrich, K. (2011). Removable nanocoatings for siRNA polyplexes. Bioconjug Chem 22, 169-179.

Kuijpers, S.A., Coimbra, M.J., Storm, G. and Schiffelers, R.M. (2010). Liposomes targeting stromal cells. Molecular Membrane Biology 27, 328-340.

Kunjachan, S., Jose, S. and Lammers, T. (2010). Understanding the mechanism of ionic gelation for synthesis of chitosan nanoparticles using qualitative techniques. Asian J Pharm 4, 148-153.

Lammers, T. (2010). Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations. Adv Drug Deliv Rev 62, 203-231.

Lammers, T., Dawson, W. and Storm, G., (2010). MediTrans: An Integrated Project focusing on targeted nanomedicines sponsored by the European Commission’s Framework Programme 6. Drug Discovery 7, 63-67.

Lammers, T., Hennink, W.E., and Storm, G. (2008). Tumour-targeted nanomedicines: Principles and practice. Brit J Cancer 99, 392-397.

Lammers, T., Kiessling, F., Hennink, W.E. and Storm, G. (2010). Nanotheranostics and image-guided drug delivery: Current concepts and future directions. Molecular Pharmaceutics 7, 1899-1912.

Lammers, T., Storm, G. and Kiessling, F. (2010). Nanomedicine formulations for combination therapies. Nano Reviews 1, 5705.

Lammers, T., Subr, V., Peschke, P., Kuehnlein, R., Ulbrich, K., Hennink, W.E., Kiessling, F., Heilmann, M., Debus, J., Huber, P.E., and Storm, G. (2008). Image-guided and passively tumor-targeted polymeric nanomedicines for radiochemotherapy. Brit J Cancer 99, 900-910.

Lammers, T., Subr, M., Ulbrich, K., Hennink, W., Storm, G. and Kiessling, F. (2010). Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy. Nano Today 5, 197-212.

Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Huber, P.E., Hennink, W.E. and Storm, G. (2009). Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials 30, 3466-3475.

Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Huber, P., Hennink, W., Storm, G. and Kiessling, F. (2010). Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy. Advanced Engineering Materials 12, B413-B421.

Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Huber, P., Hennink, W.E., Storm, G., and Kiessling, F. (2010). HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations. Nanomedicine 5, 1501-1523.

Lammers, T. and Ulbrich, K. (2010). HPMA copolymers: 30 years of advances. Adv Drug Deliv Rev 62, 119-121.

Langereis, S., Keupp, J., van Velthoven, J.L.J., de Roos, I.H.C., Burdinski, D., Pikkemaat, J.A., Grüll, H. (2009). A Temperature-Sensitive Liposomal 1H CEST and 19F Contrast Agent for MR Image-Guided Drug Delivery. J. Am. Chem. Soc. 131 (4), 1380–1381.

Lentacker, I., Wang, N., Vandenbroucke, R.E., De Smedt, S.C., Sanders, N.N. (2009). Ultrasound exposure of lipoplex coated microbubbles: intracellular rerouting can bypass their endolysosomal degradation. Molecular Pharmaceutics 6 (2), 457–467.

Leonhard, F., Collnot, E. and Lehr, C.-M. (2010). A 3-dimensional co-culture of enterocytes, monocytes and dendritic cells to model the inflamed intestinal mucosa in vitro. Molecular Pharmaceutics, 7(6), 2103–2119.

Lobatto, M.E., Fayad, Z.A., Silvera, S., Vucic, E., Calcagno, C., Mani, V., Dickson, S.D., Nicolay, K., Banciu, M., Schiffelers, R.M., Metselaar, J.M., van Bloois, L., Wu, H.S., Fallon, J.T., Rudd, J.H., Fuster, V., Fisher, E.A., Storm, G. and Mulder, W.J. (2010). Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. Molecular Pharmaceutics 7, 2020-2029.

Longo, D.L., Dastrù, W., Digilio, G., Keupp, J., Langereis, S., Lanzardo, S., Prestigio, S., Steinbach, O., Terreno, E., Uggeri, F. and Aime, S. (2011). Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T. Magn Reson Med. 65(1), 202-211.

MacAleese, L., Stauber, J. and Heeren, R.M.A. (2009). Perspectives for imaging mass spectrometry in the proteomics landscape. Proteomics 9, 819-834.

MEDITRANS (2009). Targeted Delivery of Nanomedicine (2007-2010). The Parliament Magazine Research Review 9: 44.

Merkel, O.M., Beyerle, A., Beckmann, B., Zheng, M., Hartmann, R., Stoeger, T. and Kissel, T. (2011). Off-target effects in non-viral siRNA delivery – A study on the effect of polymer genomics on in vitro cell culture models. Biomaterials 32, 2388-2398.

Merkel, O.M., Beyerle, A., Librizzi, D., Pfestroff, A., Behr, T.M., Sproat, B., Barth, P.J. and Kissel, T. (2009). Non-viral siRNA delivery to the lung – investigation of PEG-PEI polyplexes and their in vivo performance. Molecular Pharmaceutics 6(4): 1246-1260.

Merkel, O.M., Librizzi, D., Pfestroff, A., Schurrat, T., Béhé, M. and Kissel, T. (2009). In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery after novel radio labeling and purification. Bioconjugate Chemistry 20, 174-182.

Merkel, O.M., Librizzi, D., Pfestroff, A., Schurrat, T., Buyens, K., Sanders, N.N., De Smedt, S.C., Béhé, M. and Kissel, T. (2009). Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-gpoly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging. Journal of Controlled Release 138(2): 148-159.

Merkel, O.M., Mintzer, M., Librizzi, D., Samsonova, O., Dicke, T., Sproat, B., Garn, H., Barth, P., Simanek, E. and Kissel, T. (2010). Triazine dendrimers as non-viral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity. Molecular Pharmaceutics 7(4), 969–983.

Momekova, D., Momekov, G., Rangelov, S., Storm, G. and Lambov, N. (2010). Physicochemical and biopharmaceutical characterization of dipalmitoyl phosphatidylcholine liposomes sterically stabilized by copolymers bearing short blocks of lipid-mimetic units. Soft Matter 6, 591-601.

Mulder, W.J.M., Castermans, K., van Beijnum, J.R., Oude Egbrink, M.G.A., Chin, P.T.K., Fayad, E.Z.A., Lowik, C.W.G.M., Kaijzel, E.L., Storm, G., Strijkers, G.J., Griffioen, A.W. and Nicolay, K. (2009). Molecular imaging of tumor angiogenesis using avb3-integrin targeted multimodal quantum dots. Angiogenesis 12, 17-24,

Naeye B., Raemdonck K., Remaut K., Sproat B., Demeester J. and De Smedt S.C (2010). PEGylation of biodegradable dextran nanogels for siRNA delivery. European Journal of Pharmaceutical Science 40(4), 342-351.

Negri, V., Cerpa, A., López-Larrubia, P., Nieto, L., Cerdán, S. and Ballesteros, P. (2010). Nanotubular Paramagnetic Probes as Contrast Agents for Magnetic Resonance Imaging Based on the Diffusion Tensor. Angewandte Chemie 49(10), 1813-1815.

Nolte-’t Hoen, E.N.M., Boot, E.P.J., Wagenaar-Hilbers, J.P.A., van Bilsen, J.H.M., Arkesteijn, G.J.A., Storm, G., Everse, L.A., van Eden, W. and Wauben, M.H.M. (2008). Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134. Journal of Leukocyte Biology 83, 1-10.

Oerlemans, C., Bult, W., Bos, M., Storm, G., Nijsen, F. and Hennink, W. (2010). Polymeric micelles in anti-cancer therapy: targeting, imaging and triggered release. Pharmaceutical Research 27(12), 2569–2589.

Oerlemans, C., Nijsen, F., van Amersfoort, M., van Bloois, L., Heijman, E., Luijten, P., Mali, W. and Storm, G. (2011). A novel approach to identify non-palpable breast lesions combining fluorescent liposomes and magnetic resonance-guided high intensity focused ultrasound-triggered release. European Journal of Pharmaceutics and Biopharmaceutics 77(3), 458-464.

Oliveira, S., Høgset. A., Storm, G. and Schiffelers, R.M. (2008). Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo. Current Pharmaceutical Design 14, 3686-3697.

Oliveira, S., Schiffelers, R., van der Veeken, J., van der Meel, R., Vongpromek, R., van Bergen en Henegouwen, P.M.P., Storm, G. and Roovers, R.C. (2010). Downregulation of EGFR by a novel multivalent nanobody-liposome platform. Journal of Controlled Release 145, 165-175.

Paasonen, L., Romberg, B., Storm, G., Yliperttula, M., Urtti, A. and Hennink W.E. (2007). Temperature-Sensitive Poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-Coated Liposomes for Triggered Contents Release. Bioconjugate Chem., 18 (6), 2131–2136.

Pacheco-Torres, J., López, P., Ballesteros, P. and Cerdán, S. (2011). Imaging Tumor Hypoxia by Magnetic Resonance Methods. NMR in Biomedicine 24(1), 1-16.

Pacheco-Torres, J., Calle, D., Lizarbe, B., Negri, V., Ubide, C., Fayos, R., López Larrubia, P., Ballesteros, P. and Cerdán, S. (2011). Environmentally sensitive paramagnetic and diamagnetic contrast agents for Nuclear Magnetic Resonance Imaging and Spectroscopy. Current Topics in Medicinal Chemistry 11(1),115-130.

Pérez-Mayoral, E., Negri, V., Soler-Padrós, J., Cerdán, S. and Ballesteros, P. (2008). Chemistry of Paramagnetic and Diamagnetic Contrast Agents for Magnetic Resonance Imaging and Spectroscopy. pH Responsive Contrast Agents. European Journal of Radiology 67, 453 – 458.

Raemdonck, K., Demeester, J. and De Smedt, S.C. (2009). Advanced nanogel engineering for drug delivery. Soft Matter 5, 707–715.

Raemdonck, K., Naeye, B., Buyens, K., Vandenbroucke, R.E., Hogset, A., Demeester, J., and De Smedt, S.C. (2009). Biodegradable Dextran Nanogels for RNAi: Focus on Endosomal Escape and Intracellular siRNA Delivery. Advanced Functional Materials 19: 1406-1415.

Raemdonck, K., Naeye, B., Hogset, A., Demeester, J. and De Smedt S.C. (2010). Prolonged gene silencing by combining siRNA nanogels and photochemical internalization. Journal of Controlled Release 145 (3), 281-288.

Raemdonck, K., Naeye, B., Høgset, A., Demeester, J. and De Smedt, S.C. (2010). Biodegradable dextran nanogels as functional carriers for the intracellular delivery of small interfering RNA. J. Control. Release. 148, e95-96.

Raemdonck, K., Vandenbroucke, R.E., Demeester, J., Sanders, N.N. and De Smedt, S.C. (2008). Maintaining the silence: reflections on long-term RNAi. Drug Discovery Today 13, 917-31.

Raemdonck, K., Van Thienen, T.G., Vandenbroucke, R.E., Sanders N.N., Demeester, J., and De Smedt, S.C. (2008). Dextran Microgels for Time-Controlled Delivery of siRNA. Advanced Functional Materials 18 (7), 993 – 1001.

Remaut, K., Symens, N., Lucas, B., Demeester, J. and De Smedt, S.C. (2010). Efficient delivery of intact phosphodiester oligonucleotides by poly-beta-aminoesters. Journal of Controlled Release, 144 (1), 65-74.

Reul, R., Nguyen, J. and Kissel, T. (2009). Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems. Biomaterials 30, 5815-5824.

Righi,V., Roda, J.M., Paz, J., Mucci, A., Tugnoli, V., Rodriguea- Tarduchi, G., Barrios, L., Schenetti, L., Cerdán, S. and García-Martín, M.L. (2009). 1H HR-MAS and Genomic Analysis of human tumor biopsies discriminates between high and low grade astrocytomas. NMR in Biomedicine 22: 629-637.

Rijcken, C.J.F., Talelli, M., van Nostrum, C.F., Storm, G. and Hennink, W.E. (2010). Crosslinked micelles with transiently linked drugs – a versatile drug delivery system. European Journal of Nanomedicine 3, 19-24.

Rodrigues, T.B., López-Larrubia, P. and Cerdán, S. (2009). Redox Dependence and Compartmentation of (13C) pyruvate in the brain of deuterated rats bearing C6 gliomas. J. Neurochem. 109 Suppl. 1: 237-245.

Romberg, B., Flesch, F.M., Hennink, W.E. and Storm, G. (2008). Enzyme-induced shedding of a poly(amino acid)-coating triggers contents release from dioleoyl phosphatidylethanolamine liposomes. International Journal of Pharmaceutics 355, 108-113.

Romberg, B., Hennink, W.E. and Storm, G. (2008). Sheddable coatings for long-circulating nanoparticles. Pharmaceutical Research 25, 55-71.

Schiffelers, R.M., de Wolf, H.K., van Rooy, I., and Storm, G. (2007). Synthetic delivery systems for intravenous administration of nucleic acids. Nanomedicine 2, 169-181.

Schiffelers, R.M. and Storm, G. (2008) Liposomal nanomedicines as anticancer therapeutics: Beyond targeting tumor cells. International Journal of Pharmaceutics 364, 258-264.

Schillemans, J.P., Hennink, W.E. and van Nostrum, C.F. (2010). The effect of network charge on the immobilization and release of proteins from chemically crosslinked dextran hydrogels. European Journal of Pharmaceutics and Biopharmaceutics 76, 329-335.

Smith, D.F., Aizikov, K., Duursma, M.C., Giskes, F., Spaanderman, D.-J., McDonnell, L.-A., O’Connor, P.B. and Heeren, R.M.A. (2011). An External Matrix-Assisted Laser Desorption Ionization Source for Flexible FT-ICR Mass Spectrometry Imaging with Internal Calibration on Adjacent Samples. JASMS 22, 130-137.

Spaapen, R., Groen, R., Van den Oudenalder, K., Guichelaar, T., Van Elk, M., Aarts, T., Bloem, A., Storm, G., Martens, A., Lokhorst, H. and Mutis, T. (2010). Eradication of medullary multiple myeloma by CD4+ cytotoxic human T lymphocytes directed at a single minor histocompatibility antigen. Clinical Cancer Res. 16(22), 5481-5488.

Stancanello, J., Terreno, E., Delli Castelli, D., Cabella, C., Uggeri, F., and Aime, S. (2008). Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images. Contr. Media Mol. Imaging 3, 136-149.

Stauber, J., MacAleese, L., Franck, J., Claude, E., Snel, M., Kükrer Kaletas, B., Wiel, I. M. V. D., Wisztorski, M., Fournier, I. and Heeren, R. M. A. (2010). On-Tissue Protein Identification and Imaging by MALDI-Ion Mobility Mass Spectrometry. J. Am. Soc. Mass Spectrom. 21(3), 338-347.

Stefania, R., Tei, L., Barge, A., Geninatti Crich, S., Szabo, I., Cabello, C., Cravotto, G., Aime, S. (2009). Tuning Glutamine Binding Modes in Gd-DOTA-Based Probes for an Improved MRI Visualization of Tumor Cells. Chemistry - A European Journal 15, 76-85.

Storm, G. (2007). EU Project MEDITRANS van start. Conceptuur 51; 20.

Strijkers, G.J. and Nicolay, K. (2010). Relaxivity of Nanoparticles for Magnetic Resonance Imaging. In: Handbook of Nanophysics, 7 Volumes, 350 Chapters. Klaus D. Sattler, Editor. Taylor & Francis (CRC Press).

Symens, N., Walzack, R., Demeester, J., Mattaj, I., De Smedt, S.C. and Remaut, K. (2010). Nuclear inclusion of inert and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles. Drug discovery Today 15, 1082-1082.

Taban Barbu, I.M., Smith, D.F., van Breukelen, B., van der Burgt, Y.E.M., Duursma, M., Heck, A.J.R., Heeren, R.M.A. and Krijgsveld, J. (2010). On-the-fly targeted selection of labeled peptides in LC-MS base quantitative proteomics. Rapid Communications in Mass Spectrometry 24, 239-241.

Talelli, M., Iman, M., Varkouhi, A.K., Rijcken, C.J.F., Schiffelers, R.M., Etrych, T., Ulbrich, K., van Nostrum, C.F., Lammers, T., Storm, G. and Hennink, W.E. (2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials 31(30), 7797-7804.

Talelli, M., Rijcken, C.J.F, Lammers, T., Seevinck, P.R., Storm, G., van Nostrum, C.F., Hennink, W.E. (2009). Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: Towards a targeted nanomedicine suitable for image-guided drug delivery. Langmuir 25: 2060-2067.

Talelli, M.A., Rijcken, C.J.F., Oliveira, S., van Meel, R., van Bergen en Henegouwen, P.M.P., Lammers, T., van Nostrum, C.F., Storm, G. and Hennink, W.E. (2011). Nanobody – shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting. Journal of Controlled Release 151, 183-192.

Talelli, M., Rijcken, C.J.F., van Nostrum, C.F., Storm, G. and Hennink, W.E. (2010). Micelles based on HPMA copolymers. Advanced Drug Delivery Reviews 62, 231-239.

Tei, L., Mazooz, G., Barge, A., Shellef, Y., Ziv, K., Granot, D., Kalchenko, V., Dewhirst, M.W., Chaabane, L., Miragoli, L., Longo, D., Neeman, M. and Aime, S. (2010). Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity. Contrast Media Mol Imaging 5(4), 213-222.

Terreno, E., Barge, A., Beltrami, L., Cravotto, G., Delli Castelli, D., Fedeli, F., Jebasingh, B. and Aime, S. (2008). Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents. Chem. Commun. 600-602.

Terreno, E., Castelli, D.D. and Aime, S. (2010). Encoding the frequency dependence in MRI contrast media: the emerging class of CEST agents. Contrast Media Mol Imaging 5(2), 78-98.

Terreno, E., Castelli, D.D., Viale, A. and Aime, S. (2010). Challenges for molecular magnetic resonance imaging. Chem Rev. 110(5), 3019-3042.

Terreno, E., Dastrù, W., Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Longo, D. and Aime, S. (2010). Advances in metal-based probes for MR molecular imaging applications. Curr Med Chem. 17(31), 3684-3700.

Terreno, E., Delli Castelli, D., Cabella, C., Dastru, W., Sanino, A., Stancanello, J., Tei, L., and Aime, S. (2008). Paramagnetic Liposomes as Innovative Contrast Agents for Magnetic Resonance (MR) Molecular Imaging Applications. Chem. Biodiv. 5, 1901-1912.

Terreno, E., Delli Castelli, D., Milone, L., Rollet, S., Stancello, J., Violante, E., and Aime, S. (2008). First ex-vivo MRI co-localisation of two LIPOCEST agents. Contrast Media and Molecular Imaging 3, 38-43.

Terreno, E., Delli Castelli, D., Violante, E., Sanders, H.M.H.F., Sommerdijk, N.A.J.M. and Aime, S. (2009). Osmotically Shrunken LIPOCEST Agents: An Innovative Class of Magnetic Resonance Imaging Contrast Media Based on Chemical Exchange Saturation Transfer. Chem. Eur. J., 15, 1440-1448.

Terreno, E., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M., Kok, M.B., Uggeri, F. and Aime, S. (2009). Methods for an improved detection of the MRI-CEST effect. Contrast Media Mol Imaging 4: 237-47.

Terreno, E., Sanino, A., Carrera, C., Delli Castelli, D., Giovenzana, G.B., Lombardi, A. Mazzon, R. Milone, L. Visigalli, M. and Aime, S. (2008). Determination of water permeability of paramagnetic liposomes of interest in MRI field. J Inorg Biochem. 102(5-6), 1112-1119.

Vader, P., van der Aa, L.J., Engbersen, J.F.J., Storm, G. and Schiffelers, R.M. (2010). A method for quantifying cellular uptake of fluorescently labeled siRNA. Journal of Controlled Release 148, 106-109.

Van den Berg, J.H., Nuijen, B., Schumacher, T.N., Haanen, J.B.A.G., Storm, G., Beijnen, J.H. and Hennink, W.E. (2010). Synthetic vehicles for DNA vaccination. Journal of Drug Targeting 18, 1-14.

Van den Berg, J.H., Oosterhuis, K., Hennink, W.E., Storm, G., van der Aa, L.J., Engbersen, J.F.J., Haanen, J.B.A.G., Beijnen, J.H., Schumacher, T.N. and Nuijen, B. (2010). Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity. Journal of Controlled Release 141, 234-240.

Van den Berg, J.H., Quaaka, S.G.L., Beijnen, J.H., Hennink, W.E., Storm, G., Schumacher, T.N., Haanen, J.B.A.G. and Nuijen, B. (2010). Lipopolysaccharide contamination in intradermal DNA vaccination:Toxic impurity or adjuvant? International Journal of Pharmaceutics 390, 32-36.

Vandenbrouke, R.E., Lentacker, I., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2008). Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles. Journal of controlled release 126, 265-273.

Vandoorne, K., Addadi, Y. and Neeman, M. (2010). Visualizing vascular permeability and lymphatic drainage using labelled serum albumin. Angiogenesis, 13(2), 75-85.

Van Gaal, E.V.B., Oosting, R.S., Hennink, W.E., Crommelin, D.J.A. and Mastrobattista, E. (2010). Junk DNA enhances pEI-based non-viral gene delivery. International Journal of Pharmaceutics 390, 76-83.

Van Gaal, E.V.B., Spierenburg, G., Hennink, W.E., Crommelin, D.J.A. and Mastrobattista, E. (2010). Flow cytometry for rapid size determination and sorting of nucleic acid containing nanoparticles in biological fluids. Journal of Controlled Release 141, 328-338.

Van Hell, A.J., Fretz, M.M., Crommelin, D.J.A., Hennink, W.E. and Mastrobattista, E. (2010). Peptide nanocarriers for intracellular delivery of photosensitizers. Journal of Controlled Release 141, 347-353.

Van Hell, A., Klymchenko, A., Burgers, P., Moret, E., Jiskoot, W., Hennink, W.E., Crommelin, D.J.A. and Mastrobattista, E. (2010). Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles. The Journal of Physical Chemistry B 114, 11046-11052.

Van Rooy, I., Cakir-Tascioglu, S., Couraud, P.O., Romero, I.A., Weksler, B., Storm, G., Hennink, W.E., Schiffelers, R.M. and Mastrobattista, E. (2010). Identification of peptide ligands for targeting to the blood-brain barrier. Pharmaceutical Research 27, 673-682.

Van Thienen, T.G., Demeester, J. and De Smedt, S.C. (2008). Screening poly(ethyleneglycol) micro- and nanogels for drug delivery purposes. Int J Pharm. 351(1-2), 174-185.

Van Thienen, T. G., Raemdonck, K., Demeester, J., and De Smedt, S. C. (2007). Protein Release from Biodegradable Dextran Nanogels. Langmuir, 23 (19), 9794 -9801.

Van Tomme, S., Metselaar, J.M., Schiffelers, R.M. and Storm, G. (2008). Liposomal corticosteroids as targeted anti-inflammatory nanomedicine. Eur. Journal of Nanomedicine 1, 15-19.

Varkouhi, A.K., Lammers, T., Schiffelers, R.M., van Steenbergen, M.J., Hennink, W.E. and Storm, G. (2011). Gene Silencing Activity of siRNA Polyplexes Based on Biodegradable Polymers. European Journal of Pharmaceutics and Biopharmaceutics 77(3), 450-457.

Varkouhi, A., Schiffelers, R., Van Steenbergen, M., Lammers, T., Hennink, W. and Storm, G. (2010). Photochemical internalization (PCI)-mediated enhancement of gene silencing efficiency of polymethacrylates and N,N,N-trimethylated chitosan (TMC) based siRNA polyplexes. J Control Release 148, e98-99.

Varkouhi, A.K., Verheul, R.J., Schiffelers, R.M., Lammers, T., Storm, G. and Hennink, W.E. (2011). Gene Silencing Activity of siRNA Polyplexes Based on Thiolated N,N,N-trimethylated Chitosan. Bioconj. Chem. 21, 2339-2346.

Vercauteren, D., Piest, M., van der Aa, L.J., Al Soraj, M., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2011). Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes. Biomaterials 32 (11), 3072-3084.

Vercauteren, D., Vandenbroucke, R.E., Jones, A.T., Rejman, J., Demeester, J., De Smedt, S.C., Sanders, N.N. and Braeckmans, K. (2010). The use of inhibitors to study endocytic pathways of gene carriers: optimisation and pitfalls. Molecular Therapy 18(3), 561-569.

Wentzel, B. (2006). Utrecht coordineert Europees Nanomedicines project. Conceptuur 47; 24.

Zeilmaker, R. (2006). Nanomedicijnen: Geleide projectielen voor het lichaam. Intermediair 20; 48-49.

Forthcoming Journal publications:

Aizikov, K., Smith, D.F., Chargin, D., Ivanov, S., Lin, T.-Y., Heeren, R.M.A. and O'Connor, P. (2011). Vacuum Compatible Sample Positioning Device for MALDI Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Imaging. Rev. Sci. Instr., Submitted

Aychek, T., Vandoorne, K., Brenner, O., Jung, S. and Neeman, M. (2011). Quantitative analysis of intravenously administered contrast media reveals early changes in vascular barrier functions in a murine colitis model. Magnetic Resonance in Medicine, In Press

Benfer, M. and Kissel, T. (2011). Cellular uptake mechanism and knockdown activity of siRNA-loaded biodegradable DEAPA-PVA-g-PLGA-nanoparticles. Eur J Pharm Biopharm, Submitted

Benfer, M., Reul, M., Betz, R. and Kissel, T. (2011). Folic acid-decorated nanocomposites prepared by a simple solvent displacement method. J Pharmaceutical Science, Submitted

Boekhorst, B.C.M.te, Jensen, L.B., Nielsen, H.M., Foged, C. and Nicolaij, K. (2011). siRNA-loaded PLGA-nanocarriers in rheumatoid arthritis: Evaluation of the therapeutic effect of intraarticular siRNA treatment in CIA induced DBA/1 mice. Tentative title, in preparation.

Braeckmans, K., Buyens, K., Naeye, B., Vercauteren, D., Deschout, H., Raemdonck, K., Remaut, K., Sanders, N.N., Demeester, J. and De Smedt S.C. (2010). Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles. Journal of Controlled Release, In press

Buyens, K., Bouquet, W., Vervaet, C., Joye, P., De Vos, F., Plawinski, L. Doeuvre, L., Angles-Cano, E., Sanders, N.N., Demeester, J. and De Smedt, S.C. (2010). Sizing nanomatter in biological fluids by fluorescence Single Particle Tracking. Nano Letters, In press

Crielaard, B.J., Lammers, T., Morgan, M.E., Chaabane, L., Carboni, S., Greco, B., Zaratin, P., Kraneveld, A.D. and Storm, G. (2011). Macrophages and liposomes in inflammatory disease: friends or foes? International Journal of Pharmaceutics, In Press

Foged, C. (2010). siRNA delivery with lipid-based systems: Promises and pitfalls, Current Topics in Medicinal Chemistry. Submitted.

Foillard, S., Zuber, G. and Doris, E. (2011). Polyethylenimine-Carbon Nanotube Nanohybrids for siRNA mediated Gene Silencing at Cellular level. Nanoscale, In Press.

Gremse, F., Palmowski, M., Grouls, C., Lammers, T. and Kiessling, F. (2011). Virtual Elastic Sphere Processing Enables Reproducible Quantification of Vessel Stenosis in CT and MR Angiographies. Radiology, In press

Jayapaul, J., Hodenius, M., Arns, S., Lederle, W., Lammers, T., Comba, P., Kiessling, F. and Gätjens, J. (2011). FMN-coated fluorescent iron oxide nanoparticles for targeting and labeling metabolically active cancer and endothelial cells via the riboflavin carrier protein. Biomaterials, In press

Jensen, D.M.K., Jensen, L.B., Cun, D., Nielsen, H.M. and Foged, C. (2011). Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA. Submitted

Jensen, L.B., Griger, J., Naeye, B., Varkouhi, A.K., Raemdonck, K., Schiffelers, R., Storm, G., de Smedt, S., Sproat, B.S., Nielsen, H.M. and Foged, C. (2011). Comparison of polymeric siRNA nanocarriers: Gene silencing, toxicity and changed gene expression in a murine LPS-activated macrophage cell line. In preparation

Jensen, L.B., Pavan, G.M., Kasimova, M.R., Rutherford, S., Danani, A., Nielsen, H.M. and Foged, C. (2011). Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: Effect of dendrimer charge density. International Journal of Pharmaceutics, In Press

Klink, A., Hyafil, F., Rudd, J., Faries, P., Fuster, V., Mallat, Z., Meilhac, O., Mulder, WJM., Michel, J., Ramirez, F., Storm, G., Thompson, R., Turnbull, I.C., Egido, J., Martin-Ventura, J.L., Zaragoza, C., Letourneur, D. and Fayad, Z.A. (2011). Diagnostic and therapeutic strategies for small abdominal aortic aneurysms. Nature Reviews Cardiology, Advance online publication

Kluza, E., Strijkers, G.J. and Nicolay, K. (2010). 7. Multifunctional Magnetic Resonance Imaging Probes. In: Recent Results in Cancer Research - Molecular Imaging in Oncology, edited by O. Schober and B. Riemann. In press

Koocheki, S., Jensen, D.K., Bunker, M., Cun, D., Madaeni, S.S., Nielsen, H.M. and Foged, C. (2011). Chemical and structural characterization of DOTAP-modified PLGA nanoparticles loaded with siRNA and their release properties by AFM, ToF-SIMS and FTIR. In preparation

Koocheki, S., Jensen, D.K., Cun, D., Madaeni, S.S., Nielsen, H.M. and Foged, C. (2011). Freeze-drying preserves the gene silencing activity of DOTAP-modified PLGA nanoparticles loaded with siRNA. In preparation

Kunjachan, S., Jose, S., Cinu, T., Joseph, E., Kiessling, F. and Lammers, T. (2011). Macrophage-mediated drug targeting in anti-microbial therapy. Fundam Clin Pharm, In press

Kunjachan, S., Jayapaul, J., Mertens, M., Storm, G., Kiessling, F. and Lammers, T. (2011). Theranostic systems and strategies for monitoring nanomedicine-mediated drug targeting. Curr Pharm Biotech, In press

Lammers, T., Aime, S., Hennink, W., Storm, G. and Kiessling, F. (2011). Theranostic Nanomedicines. Acc Chem Res, In press

Liu, Z., Lammers, T., Ehling, J., Fokong, S., Bornemann, J., Kiessling, F. and Gätjens, J. (2011). Iron Oxide Nanoparticle-Containing Microbubble Composites as Contrast Agents for MR and Ultrasound Dual-Modality Imaging. Biomaterials, In press

Liu, Y., Samsonova, O., Sproat, B., Merkel, O. and Kissel, T. (2010). Biophysical characterization of hyper-branched polyethylenimine-graftpolycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery. Journal of Controlled Release, Submitted

MacAleese, L., Duursma, M., Klerk, L.A., Fisher, G. and Heeren, R.M.A. (2011). Protein identification with Liquid Chromatography and Matrix Enhanced Secondary Ion Mass Spectrometry (LC-ME-SIMS). J Proteomics, Accepted for publication

Merkel, O.M., and Kissel, T. (2011). Pulmonary delivery of siRNA. Accounts of Chemical Research – Special Issue on Chemistry for Gene Silencing and Delivery Submitted

Merkel, O.M. and Kissel, T. (2011). Pulmonary delivery of siRNA. Accounts of Chemical Research, Submitted

Merkel, O.M., Marsh, L., Garn, H. and Kissel, T. (2011). Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery. In: ‘Nanotechnology for Nucleic acid Delivery’ in the book series Methods in Molecular Biology.

Merkel, O.M., Urbanics, R., Bedocs, P., Rozsnyay, Z., Rosivall, L., Toth, M., Kissel, T. and Szebeni, J. (2011). In vitro and in vivo Complement Activation and Related Anaphylactic Effects Associated with Polyethylenimine and Polyethylenimine-graft-poly(ethylene glycol) Block Copolymers. Biomaterials, In press

Merkel, O.M., Urbanics, R., Bedocs, P., Rozsnyay, Z., Rosivall, L., Toth, M., Kissel, T. and Szebeni, J. (2011). Complement Activation and Related Anaphylactic Reactivity of Polyethylenimine and Polyethylenimine-graft-poly(ethylene glycol) Block Copolymers in vitro and in Pigs. Biomaterials, Submitted

Merkel, O.M., Zheng, M., Mintzer, M., Pavan, G.M., Librizzi, L., Höffken, H., Danani, A., Simanek, E. and Kissel, T. (2011). Molecular modelling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems. Journal of Controlled Release, In press

Merkel, O.M., Zheng, M., Mintzer, M.A., Pavan, G.M., Librizzi, D., Maly, M., Hoffken, M., Danani, A., Simanek, E.E. and Kissel, T. (2011). Molecular modelling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems. Journal of Controlled Release Submitted

Naeye, B., Raemdonck, K., Remaut, K., Demeester, J. and De Smedt, S.C. (2011). Matrix systems for siRNA delivery. Current Topics in Medicinal Chemistry, In press

Protti, N., Ballarini, F., Bortolussi, S., Bruschi, P., Stella, S., Geninatti, S., Alberti, D., Aime, S. and Altieri, S. (2011). Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion. Appl Radiat Isot., In press

Reul, R., Roesler, S., Benfer, M., Nguyen, J., Schmehl, T., Gessler, T., Weissmann, N., Seeger, W., Fink, L. and Kissel, T. (2009). Expression of functional folate receptors on the apical side of the mouse lung demonstrated using folate -PEG-rhodamine conjugates. In press

Spijkers, L. J. A., van den Akker, R. F. P., Janssen, B. J. A., Debets, J. J., De Mey, J. G. R., Wijesinghe, D. S., Chalfant, C. E., MacAleese, L., Eijkel, G. B., Heeren, R. M. A., Alewijnse, A. E. and Peters, S. L. M. (2010). Pivotal role for sphingolipids in endothelium-dependent contractions and blood pressure regulation in spontaneously hypertensive rats. Submitted

Stauber, J. and Heeren, R.M.A. (2009). Chapter II-4: Metal Enhanced, Matrix Enhanced SIMS, and MALDI. In: Surface Analysis and Techniques in Biology. In press.

Storm, G. and Aime, S. (2011). European commission-supported development of targeted nanomedicines: did MEDITRANS make a difference? Targeted delivery, In press

Strijkers, G.J., Kluza, E., Van Tilborg, G.A.F., Van der Schaft, D.W.J., Griffioen, A.W., Mulder, W.J.M. and Nicolay K. (2010). Multimodal liposomes for target­specific imaging and therapy of tumor angiogenesis. Angiogenesis, Submitted

Terreno, E., Boffa, C., Menchise, V., Fedeli, F., Carrera, C., Castelli, D.D., Digilio, G. and Aime S. (2011). Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes. Chem Commun, In press

Ubide-Barreda, C., Rojas, M.L., Martínez de Paz, P.J., Righi, V. and Ballesteros, P. (2010). Polymorphism of racemic imidazol-1-ylsuccinic acid derivatives. Suitable probes for extracellular pH by magnetic resonance spectroscopic imaging. Curr. Top. Med. Chem. Submitted

Van Thienen, T.G., Vercauteren, D., Van den Bossche, J., Thompson, D.H., Demeester, J. and De Smedt, S.C. (2009). Dextran nanogels with functional coatings: peg-lipid coated and ph sensitive lipid coated nanogels. International Journal of Pharmaceutics In press

Varkouhi, A.K., Foillard, S., Lammers, T., Schiffelers, R.M., Doris, E., Hennink, W.E. and Storm, G. (2011). SiRNA Delivery with Functionalized Carbon Nanotubes. International Journal of Pharmaceutics In press

Varkouhi, A.K., Mountrichas, G., Schiffelers, R.M., Lammers, T., Storm, G., Pispas, S. and Hennink, W.E. (2011). Polyplexes Based on Cationic Polymers with Strong Nucleic Acid Binding Properties. Submitted

Varkouhi, A.K., Scholte, M., Storm, G. and Haisma, H.J. (2011). Endosomal escape pathways for delivery of biological. Journal of Controlled Release, In press

Vercauteren, D., Deschout, H., Engbersen, J.F.J, Jones, A.T., De Smedt, S.C. and Braeckmans, K. (2011). Dual-color single particle tracking and dynamic colocalization for intracellular trafficking of nanomedicines. To be submitted

Weber, N.D., Merkel, O.M., Kissel, T. and Muñoz-Fernández, M.A. (2011). PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro. Journal of Controlled Release, Submitted

Conference publications:

Agrawal, P., Strijkers, G.J., van Lent, P., Blom, A., van den Berg, W., Crielaard, B., Lammers, T., Storm, G. and Nicolay, K. (2009). MRI to monitor Rheumatoid Arthritis disease progression and regression, following treatment with nanocarrier encapsulated drug. EuroNanoMedicine Abstract.

Agrawal, P., Strijkers, G.J., van Lent, P., Blom, A., van den Berg, W., Crielaard, B., Lammers, T., Storm, G. and Nicolay, K. (2009). Use of MRI and micro CT to monitor Rheumatoid Arthritis disease progression and regression in mice. ISMRM BENELUX Abstract.

Agrawal, P., Strijkers, G.J., van Lent, P., Blom, A., van den Berg, W., Storm, G. and Nicolay, K. (2008). MRI to monitor disease progress in a mouse model of Rheumatoid Arthritis. ISMRM Benelux, 10 December 2008, Antwerp, Belgium.

Amann, A. and Gress, C. (2008). Development and pre-validation of an in-vitro method for the prediction of drug-drug interactions and intestinal absorptions as a tool for drug candidate selection. 10th Expert meeting on Blood Brain Barrier and Caco-2, Bad Herrenalb, Germany.

Boye Jensen, L. (2008). Polypropylene imine dendrimers as carriers of siRNA. 7th International Conference and Workshop on Biological Barriers and Nanomedicine – Advanced Drug Delivery and Predictive non vivo Testing Technologies.

Boye Jensen, L., Mørck Nielsen, H., Boas, U., Cun, D., Pittelkow, M., Christensen, J.B., Frøkjær, S. and Foged, C. (2008). Investigations of Poly(propyleneimine) Dendrimers as Carriers for siRNA Delivery. 7th International Conference and Workshop on Biological Barriers and Nanomedicine – Advanced Drug Delivery and Predictive non vivo Testing Technologies.

Boye Jensen, L., Mørck Nielsen, H., Boas, U., Cun, D., Pittelkow, M., Christensen, J.B., Frøkjær, S. and Foged, C. (2008). Investigations of Dendrimers as siRNA Delivery System. BIO-Dendrimer – 2008 Symposium on Biomedical Properties and Applications of Dendrimers, 3-5 July 2008, Lodz, Poland.

Braeckmans, K., Buyens, K., Bouquet-Geerardyn, W., Vervaet, C., Joye, P., De Vos, F., Plawinski, L. and Angles-Cano E. (2011). Fluorescence single particle tracking for sizing of nanoparticles in undiluted biological fluids. Presentation at the Focus on Microscopy, Konstanz, Germany.

Braeckmans, K., Vercauteren, D., Buyens, K., Remaut, K., Raemdonck, K., Sanders, N., Demeester, J. and De Smedt, S. (2010). Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles. Invited speaker at the 11th European Symposium on Controlled Drug Delivery, Egmond aan Zee, the Netherlands.

Buyens, K., Braeckmans, K., Demeester, J., De Smedt, S.C. and Sanders, N.N. (2009). ‘Single particle tracking’ for studying the aggregation of cationic liposomes in whole blood. EuroNanoMedicine Abstract.

Chaabane, L., Adage, T., Aime, S., Greco, B. and Zaratin, P. (2008). 'Differential degree of Blood Brain Barrier permeability during Experimental Autoimmune Encephalomyelitis measured by Gadolinium-enhancement MRI', poster presented at the World Congress on Treatment and Research in Multiple Sclerosis ACTRIMS-ECTRIMS-LACTRIMS (Montreal, Sept. 2008).

Chughtai, S., Chughtai, K., Kiss, A., Cillero Pastor, B., MacAleese, L. and Heeren, R.M.A. (2011). Imaging Rheumatoid Arthritis: novel MS investigation of an old disease. in ASMS Denver, Colorado (USA) 2011

Chughtai, S., Chughtai, K., MacAleese, L. and Heeren, R.M.A. (2010). Imaging rheumatoid arthritis: A multimodal Mass Spectrometric investigation. in NaJaarsBijeenkomst NVMS “Mass Spectrometry In aMSterdam” Amsterdam (NL), 2010.

Collnot, E.-M., Bur, M., Leonard, F., Schmidt, C., Stallmach, A. and Lehr, C.-M. (2009). Nanoparticle in men against inflammatory bowel diseases – a promising approach for the therapy of diarrhoea. Clinam Meeting.

Collnot, E.-M., Leonard, F., Lehr, C.-M., (2009). The intestinal ‘enhanced permeability and retention effect’: a passive targeting principle for PLGA nanocarriers in the treatment of inflammatory bowel disease. Clinam Meeting.

Crielaard, B., Yousefi, A., Schillemans, J., Lammers, T. and Storm, G. (2009). Interaction of liposomes with proteins measured by Surface Plasmon Resonance correlates with their in vivo circulation time. EuroNanoMedicine: Young researcher's technical workshop.

Czornak, K., Duursma, M. C., MacAleese, L., Boersema, P. J., Mohammed, S., Heck, A. J. R., Heeren, R. M. A. and Altelaar, A. F. M. (2009). Improved On-Tissue Protein Identification in MALDI Imaging Mass Spectrometry (MSI) using the Metalloendopeptidase Lys-N. 57th American Society for Mass Spectrometry (ASMS) Conference, 2009. Philadelphia, Pennsylvania (USA)

Deschout, H., Forier, K., Vercauteren, D., Neyts, K. and Braeckmans, K. (2011). The effect of movement on the localization precision of single molecules and particles. Presentation at the Focus on Microscopy, Konstanz, Germany.

Deschout, H., Vercauteren, D., Demeester, J., De Smedt, S. and Braeckmans, K. (2010). Quantitative colocalisation of dynamic objects in fluorescence microscopy movies. Poster at the Focus On Microscopy in Shanghai.

Deschout, H., Vercauteren, D., Remaut, K., Demeester, J., De Smedt, S. and Braeckmans, K. (2010). Quantitative colocalisation of dynamic objects in fluorescence microscopy images. Poster at the Advanced Light Microscopy Symposium, Ghent (Belgium).

Folz, J., Bur, M., Collnot, E., Crielaard, B.J., Lammers, T., Storm G. and Lehr C.-M. (2009). Reduced phagocytosis of pegylated nanosized liposomes by alveolar macrophages. EuroNanoMedicine Abstract.

Foillard, S. and Doris, E. (2009). Drug Delivery Systems Based on Short Carbon Nanotubes. EuroNanoMedicine Abstract.

Giraud, S. and Maskrot, H. (2008). Synthesis of iron containing nanopowders by the laser pyrolysis method for biomedical applications. (Abstract) Particles 2008, USA

Giraud, S. Maskrot, H. Bonville, P. and Boulanger L. (2008). Characterization of inorganic magnetic nanoparticles produced by the laser pyrolysis method. International Conference on Safe production and use of nanomaterials, Nanosafe 2008 November 3-7, 2008 – Grenoble, France.

Gress, C. and Amann, A. (2008). Effects of different parameters in Caco-2 bi-directional permeability studies. 10th Expert meeting on Blood Brain Barrier and Caco-2, Bad Herrenalb, Germany.

Griger, J., Jensen, L.B., Huber, A. and Foged, C. (2010). Toxicogenomic effects of polymeric siRNA delivery in vitro. ELLS Scientific Student Conference, Copenhagen, Denmark, November 2010.

Hak, S., Sanders, E., Agrawal, P., Langereis, S., Gruell, H., Keizer, H., Arena, F., Terreno, E., Strijkers, G.J. and Nicolay, K. (2008). A High Relaxivity Gd(III)DOTA-DSPE-Based Liposomal Contrast Agent for Target-Specific MRI. Abstract for 2008 World Molecular Imaging Congress, Sept. 10–13, Nice, France.

Heeren, R.M.A. (2010). Molecular histology with mass spectrometry: imaging nanomedicine. in 8th Biological Barriers 2010 Saarland University, Saarbruecken (Germany) 2010.

Heeren, R.M.A. (2010). Molecular imaging with mass spectrometry: to boldly see what has not been seen before. in- PNNL EMSL Richland, (WA, USA) 2010.

Heeren, R.M.A. (2010). Multi-modal molecular imaging in biomedicine: using a mass spectrometer as a microscope. in Frontiers of Science seminar, BioCity, Turku, (Finland) 2010.

Heeren, R.M.A. (2010). Mass spectrometric imaging studies on biomolecular surfaces in 4th MS. in Biotechnology and Medicine symposium Dubrovnik, (Croatia) 2010.

Heeren, R.M.A. (2010). Molecular imaging with mass spectrometry: A primer in 4th MS. in Biotechnology and Medicine symposium Dubrovnik (Croatia) 2010.

Heeren, R.M.A. (2010). Imaging mass spectrometry in biomolecular surface analysis. in Finnish MS society annual conference Tampere (Finland) 2010.

Heeren, R.M.A. (2010). Molecular Microscopy: Multi-modal Tissue Imaging in Biomedicine. in 27th Montreux LC/MS symposium, Montreux, (Switzerland) 2010.

Heeren, R.M.A. and Smith, D.F. (2010). FT-ICR imaging mass spectrometry mass spectrometry: developments and application. in European FT-MS Workshop Lausanne, (Switzerland) 2010.

Jensen, D.M.K., Cun, D., Jensen, L.B., Frokjaer, S., Nielsen, H.M. and Foged, C. (2009). Spray drying preserves modified PLGA nanoparticles containing siRNA intended for inhalation and their gene silencing activity. EuroNanoMedicine Poster.

Jensen, D.M.K, Cun, D., Jensen, L.B., Frokjaer, S., Nielsen, H.M. and Foged, C. (2010). Spray drying preserves the gene silencing activity of modified PLGA nanoparticles containing siRNA intended for inhalation. American Association of Pharmaceutical Scientists, New Orleans, US, November 2010.

Jensen, L.B., Griger, J., Nielsen, H.M. and Foged, C. (2010). TNF-alpha knockdown model system for polymeric siRNA delivery using an LPS-induced macrophage cell line. ESF-UB Conference in Biomedicine on Nanomedicine: Reality Now and Soon, Sant Feliu de Guixols, Spain, October 2010.

Jensen, L.B., Mortensen, K., Jensen, D.K., Nielsen, H.M. and Foged, C. (2009). Characterization of siRNA-Dendrimer complexes by SAXS analysis. Poster presentation at 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, Copenhagen, Denmark.

Jensen, L.B., Mortensen, K., Jensen, D.K., Nielsen, H.M. and Foged, C. (2009). Characterization of siRNA-Dendrimer Complexes by SAXS Analysis. CRS Abstract.

Jensen, L. B., Mortensen, K., Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, H. M. and Foged, C. (2010). Elucidating the molecular mechanism of PAMAM-siRNA dendriplex formation: Effect of dendrimer generation and siRNA concentration. 8th European Workshop on Particulate Systems; Châtenay-Malabry, France, June 2010

Jungmann, J. H., Gademann, G., Gijsbertsen, A., MacAleese, L., Heeren, R. M. A. and Vrakking, M. J. J. (2010). Photoelectron & ion imaging using CMOS pixel detectors. Physics@FOM 2010. Veldhoven (NL)

Jungmann, J.H., Gijsbertsen, A., Heeren, R.M.A. and Vrakking M.J.J. (2010). Timepix Slicing Experiment. in Medipix Collaboration Meeting Geneva, (Switzerland) 2010.

Jungmann, J. H., MacAleese, L. and Heeren, R. M. A. (2009). Towards High Spatial Resolution in Microscope Mode Imaging MS Using a Medipix Detector. International Mass Spectrometry Conference (IMSC), 2009. Bremen (De)

Jungmann, J.H., MacAleese, L., Kharchenko, A., Buijs, R., Giskes, F., de Snaijer, A., Visser, J., Visschers, J., Vrakking, M.J.J. and Heeren, R.M.A. (2010). in ASMS Salt Lake City Utah (USA), 2010.

Jungmann, J.H., MacAleese, L., Visser, J., Visschers, J., Vrakking, M.J.J. and Heeren, R.M.A. (2011). in Physics@FOM Veldhoven (The Netherlands), 2011.

Keupp, J., Caruthers, S.D., Burdinski, D., Langereis, S., Pikkemaat, J.A., Lamerichs, R., Gruell, H., Wickline, S.A., Lanza, G.M. and Winter, P.M. (2008). Proceedings ISMRM 16th, 637.

Keupp, J., Langereis S., de Roos, I., Burdinski, D., Pikkemaat, J. and Gruell, H. (2009). 1H-CEST and 19F MRI of temperature-responsive liposomal contrast agents for image guided drug delivery. ISMRM Conference, Hawaii, 18-24 April 2009.

Kissel, T., Nguyen, J., Merkel, O., Benfer, M., Liu, Y., Endres, T. and Samsonova, O. (2009). Biodegradable nano-carriers for pulmonary drug and gene delivery. Abstract Symposium on Biomedical Polymers for Drug Delivery in Salt Lake City Utah (March 26-27, 2010).

Klerk, L. A., Jungmann, J. H., Kharchenko, A., MacAleese, L., Lockyer, N. P., Vickerman, J. C., Gademann, G., Vrakking, M. and Heeren, R. M. A. (2010). High resolution C-60 SIMS and MALDI mass microscopy using position-sensitive detectors. Physics@FOM 2010. Veldhoven (NL)

Klerk, L.A., Jungmann, J., Kharchenko, A., MacAleese, L., Lockyer, N.P., Vickerman, J.C. and Heeren, R.M.A. (2010). High resolution C-60 SIMS and MALDI mass microscopy using position sensitive detectors. in Physics@FOM Veldhoven (NL) 2010.

Lammers, T., Subr, V., Ulbrich, K., Peschke, P., Kiessling, F., Huber, P.E., Hennink, W.E., and Storm, G. (2008). Carrier-based radiochemotherapy. CRS Abstract.

Langereis, S., de Smet, M., Keupp, J., Heijman, E. and Grüll, H. (2009). Magnetic Resonance guided Imaging of Temperature Induced Drug Delivery. 2009 World Molecular Imaging Congress (WMIC) in Montreal.

Lentacker, I., De Smedt, S.C. and Sanders N. (2009). Lipoplex loaded microbubbles for ultrasound triggered gene delivery. EuroNanoMedicine Abstract.

Leonard, F., Collnot, E.-M., Crielaard, B.J., Lammers, T., Storm, G. and Lehr, C.-M. (2010). In Vitro Model of Inflammatory Bowel Disease for Screening of Drug Formulations. Globalization of Pharmaceutics Education Network: Eighth Meeting, 10-12 November 2010, UNC, Chapel Hill, USA (Podium presentation)

Leonard, F., Collnot, E.-M., Crielaard, B.J., Lammers, T., Storm, G. and Lehr, C.-M. (2010). Screening of Budesonide Formulations in In Vitro Model of Inflammatory Bowel Disease. FIP Pharmaceutical Sciences World Congress in adjunction with AAPS (American Association of Pharmaceutical Science) Annual Meeting 14-18 November 2010, New Orleans, USA (Poster)

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2008). Development of a novel 3D inflamed intestinal mucosa model: Initiation of inflammation in Caco-2 cells. 7th International Conference and Workshop on Biological Barriers and Nanomedicine – Advanced Drug Delivery and Predictive non vivo Testing Technologies.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2008). Development of a novel Caco-2 based 3D model of the inflamed intestinal mucosa: Initiation of inflammation. CRS Abstract.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2009). The intestinal ‘enhanced permeability and retention effect’: passive targeting of PLGA nanocarriers in the treatment of Crohn’s disease. EuroNanoMedicine Abstract.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2009). Development of a 3 D in vitro model of the inflamed colonic mucosa. EuroNanoMedicine: Young researcher's technical workshop.

Leonard, F., Collnot, E.-M., Lehr, C.-M. (2009). Development of a 3D in vitro model of the inflamed colonic mucosa. Congress on Alternatives & Animal Use in the Life Sciences Abstract. Rome.

Leonard, F., Collnot, E.-M., and Lehr, C.-M. (2010). Size dependent accumulation of nano- and microparticulate carriers in the inflamed intestinal tissue—A novel targeting strategy for the treatment of inflammatory bowel diseases. 37th Controlled Release Society Annual Meeting & Exposition, 10-14 July, 2010 Portland, USA (Poster)

Leonard, F., Vajda, V., Collnot, E.-M., and Lehr, C.-M. (2010). In vitro model of the intestinal mucosa in state of inflammation – adaption to high throughput applications. 8th conference and workshop on biological barriers and nanomedicine, 20-29 February 2010, Saarbrücken, Germany (Poster)

Leonard, F., Vajda, V., Collnot, E.-M., and Lehr, C.-M. (2010). In vitro model of the intestinal mucosa in state of inflammation – adaption to high throughput applications. Nanotoxicology, 2-4. June 2010, Edinburgh, Scottland (Poster)

MacAleese, L. (2010). Imaging Mass Spectrometry at AMOLF: between applications and developments. in NVMS annual meeting, University of Amsterdam Amsterdam (NL) 2010.

MacAleese, L. (2011). in USGEB (Session Organized By the Swiss Proteomics Society) Zurich (Switzerland).

MacAleese, L., Ballet, S., Corot, C. and Heeren, R. M. A. (2010). Imaging Mass Spectrometry and Nanomedicine: Contribution of Mass Spectrometry to Medical Imaging Techniques such as MRI. Physics@FOM 2010. Veldhoven (NL)

MacAleese, L., Ballet, S., Corot, C. and Heeren, R. M. A. (2009). Investigating Distribution and Concentration of MRI Contrast Agents In and Around Tumors by Imaging Mass Spectrometry. International Mass Spectrometry Conference (IMSC), 2009. Bremen (De)

MacAleese, L., Bot, M., Kharchenko, A., Biessen, E. A. L. and Heeren, R. M. A. (2009). Lipid Cartography of Atherosclerotic Plaques by ToF-SIMS Imaging Mass Spectrometry. Physics@FOM 2009. Veldhoven (NL)

MacAleese, L., Bot, M., Kharchenko, A., Biessen, E. A. L. and Heeren, R. M. A. (2009). Lipid Cartography of Atherosclerotic Plaques by ToF-SIMS Imaging Mass Spectrometry. Netherlands Proteomics Center Annual Meeting, 2009. Utrecht (NL)

MacAleese, L., Eijkel, G.B., Ballet, S., Corot, C., Heeren, R.M.A. (2010). Physics for molecular pathology: a multi-modal molecular imaging approach. Imaging Mass Spectrometry and Nanomedicine: Contribution of Mass Spectrometry to Medical Imaging Techniques such as in Physics@FOM Veldhoven (NL) 2010

MacAleese, L., Eijkel, G.B., Spijkers, L.J.A., Alewijnse, A.E., Peters, S.L.M. and Heeren, R.M.A. (2010). New Tools and Workflows for Rationalized Chemical Analysis in Imaging Mass Spectrometry: Case of Lipids. in Hypertensive Rat Artery Sections in ASMS Salt Lake City Utah (USA), 2010.

MacAleese, L., Eijkel, G.B., Spijkers, L.J.A., Alewijnse, A.E., Peters, S.L.M. and Heeren, R.M.A. (2010). New Tools and Workflows for Rationalized Chemical Analysis in Imaging Mass Spectrometry: Case of Lipids in Hypertensive Rat Artery Sections. in 58th ASMS Conference on Mass Spectrometry and Allied Topics Salt Lake City, Utah (USA) 2010.

MacAleese, L., Klerk, L. A., Smith, D. F., Duursma, M. C. and Heeren, R. M. A. (2009). LC-SIMS: a Tool for Molecular Identification, and Enhanced Impact of SIMS in Biological Fields. European Proteomics Association (EuPA), 2009. Stockholm (Sweden)

MacAleese, L., Klerk, L. A., Smith, D. F., Duursma, M. C. and Heeren, R. M. A. (2009). LC-SIMS: The Doors Wide Open for Biological Applications of SIMS in Imaging Mass Spectrometry. 57rd American Society for Mass Spectrometry (ASMS) Conference, 2009. Philadelphia, Pennsylvania (USA)

MacAleese, L., Stauber, J. and Heeren, R.M.A. (2008). Imaging MS/MS: challenges for on-tissue protein identification. HUPO 7th Annual World Congress, Amsterdam (NL) 16-20.08.08.

Merkel, O.M., Beyerle, A., Librizzi, D. and Kissel, T. (2009). Imaging-guided Gene & Cell based Therapies Nuclear Imaging of Intratracheal siRNA Delivery with PEG-PEI Copolymers. 4th European Molecular Imaging Meeting - Barcelona 27-30 May 2009.

Naeye B., Raemdonck K., Demeester, J., De Smedt S.C. (2008). Pegylation of biodegradable dextran nanogels for controlled siRNA release. ESF-UB conference: Nanomedicine 2008, Sant Feliu de Guixols, Spain.

Naeye, B., Raemdonck, K., Demeester, J. and De Smedt, S.C. (2010). Interactions of siRNA loaded dextran nanogels with blood cells. Poster at the 11th European Symposium on Controlled Drug Delivery, Egmond-aan-zee (The Netherlands).

Naeye B., Raemdonck K., and De Smedt S.C. (2009). Optimization of biodegrabable dextran nanogels for controlled siRNA delivery. EuroNanoMedicine Abstract.

Naeye, B., Raemdonck, K., Deschout, H., Röding, M., Rudemo, M., Braeckmans, K. and De Smedt, S.C. (2010). Predicting the fate of nanocarriers after intravenous injection. Poster at the Advanced Light Microscopy Symposium, Ghent (Belgium).

Naeye, B., Raemdonck, K. and De Smedt, S.C. (2010). Optimization of biodegradable dextran nanogels for controlled siRNA delivery. Poster at the ESF Research Conference Nanomedicine: Reality now and soon, San Feliu, Barcelona, Spain.

Naeye, B., Raemdonck, K. and De Smedt, S.C. (2010). Nanoparticle interactions with blood. Presentation at the ESF Research Conference Nanomedicine: Reality now and soon, San Feliu, Barcelona, Spain.

Oerlemans, C., Nijsen, J.F.W., van Amersfoort, M., van Bloois, L., van den Bosch, M.A., Luijten, P.R. and Storm, G. (2009). Dye-containing liposomes for heat-triggered release. EuroNanoMedicine: Young researcher's technical workshop.

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Intracellular time-controlled delivery of siRNA from cationic nanogel depots. 11th annual Meeting of the American Society of Gene Therapy (ASGT), May 28-June 1, Boston, Massachusetts, USA

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Cytosolic nanogel depots for time-controlled siRNA delivery. 2nd International Symposium on Cellular Delivery of Therapeutic Macromolecules Cardiff University, June 22nd – June 25th

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Cytosolic nanogel depots for time-controlled siRNA delivery. September 16th – September 18th, Stockholm international fairs and congress center, Stockholm, Sweden.

Raemdonck, K., Demeester, J., De Smedt, S.C. (2008). Cytosolic nanogel depots for time-controlled siRNA delivery. Right Symposium “RNA interference technology as Human Therapeutic Tool”, 3-5 November, The International Auditorium, Brussels

Raemdonck, K., Naeye, B., De Backer, L., Demeester, J. and De Smedt, S. (2011). Evaluation of dextran nanogels as functional and hemocompatible carriers for siRNA delivery. Poster at the 15th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, USA.

Raemdonck, K., Naeye B., Demeester, J., De Smedt, S.C. (2009). Evaluation of a dextran nanogel concept for intracellular siRNA delivery. EuroNanoMedicine Abstract.

Raemdonck, K., Naeye, B., Hogset, A., Demeester, J. and De Smedt, S.C. (2010). Biodegradable dextran nanogels as functional carriers for the intracellular delivery of small interfering RNA. Poster at the 11th European Symposium on Controlled Drug Delivery, Egmond-aan-zee (The Netherlands).

Raemdonck, K., Naeye, B., Hogset, A., Demeester, J. and De Smedt, S.C. (2010). Biodegradable dextran nanogels as functional carriers for the intracellular delivery of small interfering RNA. Poster at the RNAi & miRNA Europe, Dublin (Ireland).

Ratzinger, G., Agrawal, P., Wirth, M., Körner, W., Nicolay, K. and Gabor, F. (2009). Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging. Presented at the 21st Scientific Congress of the Austrian Pharmaceutical Society April 16th to April 18th 2009, Vienna, Austria.

Remaut, K., Symens, N., Vandenbroucke, R., Sanders, N.N., Demeester, J. and De Smedt, S.C. (2010). Plasmid transfer to the nucleus. Invited speaker at the ESF Research Conference Nanomedicine: Reality now and soon, San Feliu, Barcelona, Spain.

Schiffelers, R., Oliveira, S., Woodle, M., Hogset, A. and Storm, G. (2008). TARGETED NANOMEDICINES DELIVERING siRNA. Potentiation of Silencing Activity by Photochemical Internalization. CRS Abstract.

Schmidt, C., Collnot, E.-M., Bojarski, C., Schumann, M., Schulzke, J.-D., Lehr, C.-M., and Stallmach, A. (2010). Confocal laser endomicroscopy (CLE) reveals mucosal accumulation of PLGA-nanoparticles in ulcerous lesions of patients with inflammatory bowel diseases. Digestive Disease Week 2010, 1-6 May 2010, New Orleans, LA, USA (Poster)

Sheikhet Migalovich, H., Addadi, Y., Nevo, N., Ballet, S., Corot, C., Neeman, M. (2010). Loss of Selectivity for folate receptor tumor targeting of USPIO by Macrophage uptake. ISMRM – Stockholm, Sweden 1-7 May 2010.

Smith, D.F., Duursma, M.C. and Heeren, R.M.A. (2010). Advantages of FT-ICR MS for Mass Spectrometry Imaging. in Physics@FOM Veldhoven (NL) 2010.

Smith, D.F., Duursma, M.C. and Heeren, R.M.A. (2010). Instrumentation and Methods Development for FT-ICR Mass Spectrometry Imaging. in European FT-MS Workshop Lausanne, (Switzerland) 2010.

Smith, D.F., Duursma, M.C., Kharchenko, A. aNd Heeren, R.M.A. (2010). FT-ICR Mass Spectrometry Imaging: Method Development for Vacuum and Atmospheric Pressure Biological Tissue Analysis Sections. in 58th ASMS Conference on Mass Spectrometry and Allied Topics Salt Lake City, Utah (USA) 2010.

Stauber, J., Klerk, L., van Bochove, G.S., Nicolay, K. and Heeren, R.M.A. (2008). A Combined Imaging Mass spectrometry and MRI study of nanoparticle based drug delivery
systems. HUPO 7th Annual World Congress, Amsterdam (NL) 16-20.08.08.

Stauber, J., Kükrer-Kaletas, B., van der Wiel, I.M., Heeren, R.M.A., Snel, M.F. and Claude, E. (2008). Ion mobility Imaging Mass Spectrometry: A New Tool for In situ Identification. 56th ASMS Conference on Mass Spectrometry and Applied Topics, Dencer, CO (USA). 1-5.06.08.

Stauber J., MacAleese L., Franck J., Snel M., Claude E., Kükrer Kaletas B., Wiel I. M. van der, Wisztorski M., Fournier I. and Heeren, R.M.A. (2008). Targeted Ion Mobility Imaging Mass Spectrometry: A new tool for In situ identification. HUPO 7th Annual World Congress, Amsterdam (NL) 16-20.08.08.

Storm, G. (2009). MEDITRANS: Targeted Delivery of Nanomedicine. EuroNanoMedicine Abstract.

Symens, N., Walczak, R., Demeester, J., Mattaj, I., De Smedt, S. and Remaut, K. (2010). Nuclear inclusion of inert and chromatin-targeted polystyrene beads and DNA/PEI polyplexes. Poster at the 11th European Symposium on Controlled Drug Delivery, Egmond-aan-zee (The Netherlands). Poster was awarded the Jan Feijen Poster award.

Symens, N., Walczak, R., Demeester, J., Mattaj, I., De Smedt, S. and Remaut, K. (2010). Nuclear inclusion of inert and chromatin-targeted polystyrene beads and DNA/PEI polyplexes. Poster at the 3rd International Symposium: Cellular Delivery of Therapeutic Macromolecules, Cardiff, Wales.

Symens, N., Walczak, R., Demeester, J., Mattaj, I., De Smedt, S. and Remaut, K. (2010). Nuclear inclusion of inert and chromatin-targeted polystyrene beads and DNA/PEI polyplexes. Poster at the 37th Annual Meeting of the Controlled Release Society, Portland, USA.

Symens, N., Walczak, R., Demeester, J., Mattaj, I., De Smedt, S.C. and Remaut, K. (2011). Nuclear inclusion of inert and chromatin-targeted polystyrene beads and DNA/PEI polyplexes. Poster at the 15th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, USA.

Vercauteren, D., Al Soraj, M., Piest, M., Van der Aa, H., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2010). Unraveling the cellular uptake of bioreducible poly(amido amine) - gene complexes in cells of the retinal pigment epithelium. Poster at the 11th European Symposium on Controlled Drug Delivery, Egmond-aan-zee (The Netherlands).

Vercauteren, D. Al Soraj, M., Piest, M., Van der Aa, H., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans K. (2010). Unraveling the cellular uptake of bioreducible poly(amido amine) - gene complexes in cells of the retinal pigment epithelium. Poster at the Scientific afternoon FFW, Ghent, Belgium.

Vercauteren, D., Deschout, H., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2010). Mapping the intracellular trafficking of bioreducible poly(amido amine) - gene complexes in cells of the retinal pigment epithelium. Poster at the Advanced Light Microscopy Symposium, Ghent (Belgium).

Vercauteren, D., Deschout, H., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2011). Mapping the intracellular trafficking of bioreducible poly(amido amine)-gene carriers by quantitative live-cell fluorescence colocalization studies. Presentation at the 2d joint meeting UCL-UGent nanomedicine, UCL, Louvain La Neuve, Belgium.

Vercauteren, D., Deschout, H., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2011). Dual-color Single Particle Tracking and dynamic colocalization for intracellular trafficking of nanomedicines. Presentation at the Focus on Microscopy, Konstanz, Germany.

Vercauteren, D., Deschout, H., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2011). Mapping in vitro the intracellular trafficking of nanomedicines. Poster at the Flanders Bio 7th edition of its annual life sciences convention “Knowledge for Growth” Ghent, Belgium.

Vercauteren, D., Piest, M., Al Soraj, M., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C. and Braeckmans, K. (2010). Endocytosis and intracellular processing of bioreducible polyamidoamine - gene complexes in cells of the retinal pigment epithelium. Presentation at the Controlled release Society, 37th annual meeting and exposition: Perzonalized medicines and products for the next generation, Portland, Oregon, U.S.A.

Vercauteren, D., Vandenbroucke, R.E., Demeester, J., Jones, A.T., De Smedt, S.C., Sanders, N.N. and Braeckmans, K (2010). The use of endocytic inhibitors vs molecular techniques (siRNA, mutant proteins) for studying endocytic uptake. Invited lecture at the 3rd International Symposium: Cellular Delivery of Therapeutic Macromolecules, Cardiff, Wales.

UNITO (2007). Inclusion and Aggregation Properties of an Anionic Porphyrin with Ionic and Non-Ionic Cyclodextrin Vesicles for Diagnostic Applications. 19-22 September 2007 – Poster presented at the 8th National Congress on Supramolecular Chemistry held in Trieste (Italy).

Theses:

V. Gadzhyeva. (2010). Characterization of PAMAM-siRNA complexes of generation G1, G4 and G7 at different molar ratios. Master thesis. University of Copenhagen.

J. Griger. Master thesis, University of Copenhagen/Universität Hohenheim, Stuttgart, Germany, November 2009.

L.B. Jensen. (2011). Polymeric siRNA nanocarriers for anti-arthritic therapy: From physicochemical characterization to in vivo imaging. PhD thesis, University of Copenhagen, planned submission 1/5-2011

S.S. Oliveira. Utrecht 08-12-08. Title: Epidermal growth factor receptor: Target for delivery and silencing. Promotor: Prof. Dr. G. Storm. Copromotor, Dr. R.M. Schiffelers.

E.V.B. van Gaal, (2010). DNA-Transporting Nanoparticles. Design and in vitro evaluation of DNA. Promotor: prof.dr. D.J.A. Crommelin, prof.dr.ir. W.E. Hennink; Co-promotor: dr. E. Mastrobattista, dr. R.S. Oosting.

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The MR image of the brain used on this website is from: Dousset V, Brochet, B, Deloire MSA, Lagoarde L, Barroso B, Caille J-M, Petry KG. MR imaging of relapsing multiple sclerosis patients using ultra-small particle iron oxide and compared to gadolinium. AJNR - Am J NeuroRadiology 2006; 27(5):1000-5.